Child's Nervous System

, 25:655

Interstitial continuous infusion therapy in a malignant glioma model in rats

Authors

  • Yuichi Tange
    • Division of Pediatric NeurosurgeryChildren’s Memorial Hospital
    • Division of Pediatric NeurosurgeryChildren’s Memorial Hospital
    • Cancer Biology and Epigenomics Program, Department of Pediatrics, Children’s Memorial Medical CenterNorthwestern University, Feinberg School of Medicine
  • Merrill J. Egorin
    • University of Pittsburgh Cancer Institute
  • Barbara Mania-Farnell
    • Department of Biological SciencesPurdue University Calumet
  • Georgy M. Daneriallis
    • Division of Pediatric NeurosurgeryChildren’s Memorial Hospital
  • Hiromichi Nakazaki
    • Division of Pediatric NeurosurgeryChildren’s Memorial Hospital
  • Simone T. Sredni
    • Cancer Biology and Epigenomics Program, Department of Pediatrics, Children’s Memorial Medical CenterNorthwestern University, Feinberg School of Medicine
  • Veena Rajaram
    • Division of Anatomic PathologyChildren’s Memorial Hospital
  • Stewart Goldman
    • Division of Hematology/Oncology/TransplantationChildren’s Memorial Hospital
  • Marcelo B. Soares
    • Cancer Biology and Epigenomics Program, Department of Pediatrics, Children’s Memorial Medical CenterNorthwestern University, Feinberg School of Medicine
  • Tadanori Tomita
    • Division of Pediatric NeurosurgeryChildren’s Memorial Hospital
Original Paper

DOI: 10.1007/s00381-008-0805-3

Cite this article as:
Tange, Y., Kondo, A., Egorin, M.J. et al. Childs Nerv Syst (2009) 25: 655. doi:10.1007/s00381-008-0805-3

Abstract

Purpose

Local direct delivery of chemotherapeutic agents for the treatment of brain tumors is an area of focus in the development of new therapeutic paradigms. These techniques need improvement, especially in terms of drug retention in brain tissue.

Materials and methods

In this study, we used a rat glioma model to examine carboplatin distribution, as measured by platinum penetration, after delivery via interstitial continuous (i.c.) infusion. We also examined rat survival times in response to carboplatin and oxaliplatin. I.C. infusion, a modified version of convection-enhanced delivery (CED) for local drug delivery, uses low volume (1 μl per hour) continuous infusion directly into the tumor.

Results

I.C. infusion produced a nearly 360-fold higher concentration of platinum in tumor tissue and significantly prolonged rodent survival time compared to intraperitoneal (i.p.) infusion.

Conclusions

We showed i.c. infusion allows for circumvention of the blood–brain barrier, focused drug distribution, and sustained drug delivery. This method could be a promising strategy for treating brain tumors.

Keywords

Convection-enhanced deliveryCarboplatinOxaliplatinChemotherapyRat model

Copyright information

© Springer-Verlag 2009