Child's Nervous System

, Volume 25, Issue 1, pp 47–54

Modulating effect of apolipoprotein E polymorphisms on secondary brain insult and outcome after childhood brain trauma

  • T. Y. M. Lo
  • P. A. Jones
  • I. R. Chambers
  • T. F. Beattie
  • R. Forsyth
  • A. D. Mendelow
  • R. A. Minns
Original Paper

DOI: 10.1007/s00381-008-0723-4

Cite this article as:
Lo, T.Y.M., Jones, P.A., Chambers, I.R. et al. Childs Nerv Syst (2009) 25: 47. doi:10.1007/s00381-008-0723-4

Abstract

Objective

The aim of this study was to determine the relationship between apolipoprotein E (APO E) alleles, the amount of cerebral perfusion pressure (CPP) insult and outcome in children after brain trauma.

Materials and methods

In a prospective two-centre case–control study, the APO E genotypes of 65 critically ill children admitted after brain trauma were correlated with age-related CPP insult quantification, conscious state at the time of discharge from intensive care and global outcome at 6 months post-injury. One hundred sixty healthy age- and sex-matched children were genotyped as controls.

Results

The CPP insult level among the e4 carriers with poor outcome was significantly less than the non-e4 carriers (p = 0.03). Homozygotic e3 patients with good recovery did so despite having suffered nearly 26 times more CPP insult than those who were not e3 homzygous (p = 0.02).

Conclusion

Different APO E alleles may potentially affect cerebral ischaemic tolerance differently in children after brain trauma.

Keywords

Traumatic brain injury Apolipoprotein E genetic polymorphisms Cerebral perfusion pressure Outcome GCS Paediatrics 

Copyright information

© Springer-Verlag 2008

Authors and Affiliations

  • T. Y. M. Lo
    • 1
    • 2
  • P. A. Jones
    • 1
  • I. R. Chambers
    • 3
  • T. F. Beattie
    • 2
  • R. Forsyth
    • 3
  • A. D. Mendelow
    • 3
  • R. A. Minns
    • 1
    • 2
  1. 1.Section of Child Life & HealthUniversity of EdinburghEdinburghUK
  2. 2.Royal Hospital for Sick ChildrenEdinburghUK
  3. 3.Newcastle General HospitalNewcastle-upon-TyneUK

Personalised recommendations