Original Paper

Child's Nervous System

, 25:63

First online:

Paravertebral malignant tumors of childhood: analysis of 28 pediatric patients

  • Dilek GunesAffiliated withDepartment of Pediatric Oncology, Dokuz Eylul University Institute of Oncology Email author 
  • , Kamer Mutafoglu UysalAffiliated withDepartment of Pediatric Oncology, Dokuz Eylul University Institute of Oncology
  • , Hilal CetinkayaAffiliated withDepartment of Pediatrics, Dokuz Eylul University Medical School
  • , Hande Gazeteci TekinAffiliated withDepartment of Pediatrics, Dokuz Eylul University Medical School
  • , Nurullah YuceerAffiliated withDepartment of Neurosurgery, Dokuz Eylul University Medical School
  • , Faik SarialiogluAffiliated withDepartment of Pediatric Oncology, Baskent University Medical School
  • , Nur OlgunAffiliated withDepartment of Pediatric Oncology, Dokuz Eylul University Institute of Oncology

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Abstract

Purpose

To evaluate the clinical features and treatment results of the primary paravertebral malignant tumors (PMTs) in our department.

Methods

Medical records of 28 children with primary PMTs treated between 1988–2007 were analyzed retrospectively.

Results

Primary PMTs constituted 4.8% of the cancer cases in our department. Tumor diagnoses were mostly neuroblastoma (46.4%) and soft tissue sarcomas (35.7%). These cases presented with pain (64.3%), motor dysfunction (42.8%), sphincter dysfunction (35.7%), palpable mass (32.1%), and sensory deficits (7.1%). All tumors were extradural. Physical examination revealed motor deficits (53.6%), deep tendon reflex alterations (53.6%), sphincter dysfunction (35.7%), pathologic reflexes (25%), abnormal cutaneous reflexes (25%), and sensory deficits (17.8%). Sixteen had cord compression (CC; 13 clinical, three radiological CC). Eleven of them presented with advanced disease. Seven were managed by surgical departments by primary surgery (three unresponsive). Others were managed by pediatric oncology: five with corticosteroids ± chemotherapy (one unresponsive), one with radiotherapy (RT), and two with surgery for the clinical CC. Surgery was tumor excision in nine, laminectomy in nine, laminotomy in one, and delayed surgery after chemotherapy in two cases. In chemotherapy and surgery groups, there were neurologic sequela associated with the advanced disease at diagnosis in 38% and 37%, respectively. At 3-year median follow-up, nine patients died, 17 are alive (four with neurologic sequela), and two are lost of follow-up.

Conclusion

Majority of cases presented with advanced disease. Late referral is the major cause of morbidity and mortality. The CC caused by PMTs should be initially managed with corticosteroids ± chemotherapy to avoid the adverse late effects of RT and surgery.

Keywords

Paravertebral malignant tumors Spinal cord compression Childhood