Child's Nervous System

, 24:1385

Malignant glioblastomatous transformation of a low-grade glioma in a child

  • Ekrem Unal
  • Yavuz Koksal
  • Omer Cimen
  • Yahya Paksoy
  • Lema Tavli
Case-based Update

DOI: 10.1007/s00381-008-0716-3

Cite this article as:
Unal, E., Koksal, Y., Cimen, O. et al. Childs Nerv Syst (2008) 24: 1385. doi:10.1007/s00381-008-0716-3

Abstract

Background

The term of low-grade glioma addresses a favorable clinical outcome with indolent histological features in general consideration; however, recent studies underline the inconsistency, which originates from the accumulation of different histologic subtypes in this terminology. The malignant transformation of a low-grade glioma is unusual but presents a poor prognosis.

Case history

We report a case of a 12-year-old boy, who was referred for complaints of recurrent seizures. His physical examination was unremarkable, but it was learned that a peripheral mass lesion located on the left posterior parietal lobe—which had been thought to be a low-grade glioma—had been detected on a magnetic resonance imaging 2 years ago at a different hospital. The patient was then treated with valproate and carbamazepine for the seizures and advised to be followed up without any additional diagnostic and therapeutic studies for his suspected low-grade glioma. A recent magnetic resonance imaging study showed enlargements of the mass and surrounding edema with additional necrosis. Surgical excision of the tumor was performed. After the diagnosis of glioblastoma multiforme, the patient received radiation therapy and chemotherapy with a good clinical recovery without any evidence of residue or recurrence at 12-month follow-up.

Conclusion

The first line treatment modality in the management of low-grade glioma—especially in suitable patients—is clearly surgery. The gross total resection guarantees the distinguishing of the histological types of the low-grade gliomas and reflects the biologic behavior of these tumors. Observation without surgery must be reserved for selected unoperable cases.

Keywords

Children Low-grade glioma Malignant transformation Observation without surgery Surgical resection 

Copyright information

© Springer-Verlag 2008

Authors and Affiliations

  • Ekrem Unal
    • 1
  • Yavuz Koksal
    • 2
  • Omer Cimen
    • 1
  • Yahya Paksoy
    • 3
  • Lema Tavli
    • 4
  1. 1.Department of Pediatrics, Meram Faculty of MedicineSelcuk UniversityMeram, KonyaTurkey
  2. 2.Division of Pediatric Oncology, Department of Pediatrics, Meram Faculty of MedicineSelcuk UniversityKonyaTurkey
  3. 3.Department of Radiology, Meram Faculty of MedicineSelcuk UniversityKonyaTurkey
  4. 4.Department of Pathology, Meram Faculty of MedicineSelcuk UniversityKonyaTurkey

Personalised recommendations