Child's Nervous System

, Volume 23, Issue 9, pp 1033–1040

Deep brain stimulation for torsion dystonia in children

Special Annual Issue

DOI: 10.1007/s00381-007-0382-x

Cite this article as:
Alterman, R.L. & Tagliati, M. Childs Nerv Syst (2007) 23: 1033. doi:10.1007/s00381-007-0382-x

Abstract

Introduction

Deep brain stimulation (DBS) at the internal globus pallidus (GPi) is an effective treatment for some patients with medically refractory torsion dystonia. In this article, we review the results of pallidal DBS surgery in children with dystonia. Details of the DBS procedure and programming of the DBS devices are discussed.

Discussion

Pallidal DBS is most effective in patients with primary generalized dystonia. Children and adolescents possessing the DYT1 gene mutation may respond best of all. The presence of static dystonic postures and/or fixed orthopedic contractures may limit the functional response to DBS and may require additional surgery.

Conclusion

As a group, patients with secondary dystonias respond less well to DBS than patients with primary dystonia. However, patients with dystonia secondary to anoxic brain injury who have grossly intact basal ganglia anatomy may represent a subpopulation for whom pallidal DBS is a viable option.

Keywords

Deep brain stimulationDystoniaGlobus pallidusDYT1Stereotactic surgery

Copyright information

© Springer-Verlag 2007

Authors and Affiliations

  1. 1.Department of NeurosurgeryMount Sinai Medical CenterNew YorkUSA
  2. 2.Department of NeurologyMount Sinai School of MedicineNew YorkUSA