Child's Nervous System

, Volume 22, Issue 9, pp 1201–1207

Metachronous secondary atypical meningioma and anaplastic astrocytoma after postoperative craniospinal irradiation for medulloblastoma

  • Andrew J. Hope
  • David B. Mansur
  • Pang-Hsien Tu
  • Joseph R. Simpson
Case Report

DOI: 10.1007/s00381-006-0062-2

Cite this article as:
Hope, A.J., Mansur, D.B., Tu, PH. et al. Childs Nerv Syst (2006) 22: 1201. doi:10.1007/s00381-006-0062-2
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Abstract

Introduction

Malignant brain tumors have been reported to occur after childhood irradiation more frequently than in the nonirradiated population.

Discussion

In this study, we report the case of a 15-year-old boy treated for medulloblastoma with surgery and craniospinal radiotherapy, who developed a meningioma 18 years after initial treatment and subsequently an anaplastic astrocytoma 23 years after primary treatment. The meningioma was resected without complications. The patient is currently alive but with recurrent astrocytoma after a complete remission on temozolomide monotherapy. Second malignancies are a rare, potentially devastating risk in cancer survivors, with risk continuing lifelong.

Keywords

Second malignancyMedulloblastomaAstrocytomaMeningiomaRadiation

Copyright information

© Springer-Verlag 2006

Authors and Affiliations

  • Andrew J. Hope
    • 1
  • David B. Mansur
    • 1
  • Pang-Hsien Tu
    • 2
  • Joseph R. Simpson
    • 1
  1. 1.Department of Radiation OncologyWashington University School of MedicineSt. LouisUSA
  2. 2.Department of Pathology and ImmunologyWashington University School of MedicineSt. LouisUSA