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High-sensitivity cardiac troponin T level is associated with angiographic complexity of coronary artery disease: a cross-sectional study

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Abstract

High levels of high-sensitivity cardiac troponin T (hs-cTnT) are associated with coronary artery disease (CAD). The SYNTAX score (SXscore) is an angiographic tool used to grade the complexity and extent of CAD. We investigated the relationship between hs-cTnT levels and SXscore. We conducted a cross-sectional analysis of 408 patients who underwent first diagnostic coronary angiography between December 2011 and December 2012. SXscore was recorded, and serum hs-cTnT levels were measured in all patients. The median hs-cTnT level was 0.009 μg/L. Elevated hs-cTnT levels (≥0.014 μg/L) were observed in 136 patients (33 %). Twenty-seven patients (7 %) had complex CAD as defined by intermediate or high SXscores. The levels of hs-cTnT were significantly higher in patients with high or intermediate SXscores than in those with low SXscores (0.044 ± 0.055 vs. 0.018 ± 0.058 μg/L, p = 0.03). Multivariate analysis identified hs-cTnT level, and diabetes mellitus as independent predictors for complex CAD. The adjusted odds ratio of hs-cTnT level for predicting complex CAD was 2.86 (95 % confidence interval 1.90–4.45, p < 0.0001). Predictive value of the adjusted area under the receiver operating characteristic curve for complex CAD significantly improved after inclusion of the hs-cTnT (C statistic, 0.882 vs. 0.784). Measurement of serum hs-cTnT level has an important role in the risk stratification of patients who have a plan for diagnostic coronary angiography. In patients with clinically stable angina pectoris, slightly elevated hs-cTnT levels may indicate the presence of complex CAD.

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Acknowledgments

We confirm that this manuscript has not been published and is not being considered for publication. All the authors have significantly contributed to this work, have read the manuscript, and approved its submission. This research received no grant from any funding agency in the public, commercial, or not-for-profit sectors.

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All authors have no financial conflicts of interest to disclose concerning the manuscript.

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Correspondence to Raisuke Iijima.

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K. Yamazaki and R. Iijima contributed equally to this work.

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Yamazaki, K., Iijima, R., Nakamura, M. et al. High-sensitivity cardiac troponin T level is associated with angiographic complexity of coronary artery disease: a cross-sectional study. Heart Vessels 31, 890–896 (2016). https://doi.org/10.1007/s00380-015-0689-6

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  • DOI: https://doi.org/10.1007/s00380-015-0689-6

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