Heart and Vessels

, Volume 30, Issue 1, pp 89–97

Fasudil improves short-term echocardiographic parameters of diastolic function in patients with type 2 diabetes with preserved left ventricular ejection fraction: a pilot study

  • Rong Guo
  • Yang Su
  • Jing Yan
  • Hui Sun
  • Jiakang Wu
  • Weijing Liu
  • Yawei Xu
Original Article

DOI: 10.1007/s00380-013-0458-3

Cite this article as:
Guo, R., Su, Y., Yan, J. et al. Heart Vessels (2015) 30: 89. doi:10.1007/s00380-013-0458-3

Abstract

Left ventricular (LV) diastolic dysfunction is observed frequently in patients with type 2 diabetes; however, few studies have focused on the effect of the Rho-associated kinase inhibitor fasudil on cardiac performance in humans. We conducted a prospective pilot study to assess the impact of fasudil on LV diastolic function in patients with diabetes without systolic dysfunction. Two hundred and fifty eligible patients with type 2 diabetes (149 men [61.3 %] and 94 women [38.7 %]) with a mean age of 57.2 years were randomly assigned to fasudil (n = 122, 30 mg intravenously twice a day for 14 days) or placebo (n = 121) groups. Echocardiographic variables were measured at the baseline and 1 month after the intervention. Compared with the placebo group, the fasudil group showed a significant decrease in diastolic blood pressure and in the peak of late diastolic transmitral flow (Am) (P < 0.05 for both). Deceleration time (DT), isovolumic relaxation time (IVRT), the peak of early diastolic annular velocity (e′), the peak of late diastolic annular velocity, and E/e′ also exhibited a significant improvement (all, P < 0.05) after fasudil administration. Furthermore, the Em/Am ratio and IVRT, DT, and E/e′ values recorded after fasudil treatment in the subgroup with impaired LV relaxation significantly differed from the corresponding values in the subgroup with normal LV relaxation (all, P < 0.05). Fasudil improves short-term echocardiographic parameters of LV diastolic function in patients with type 2 diabetes with preserved left ventricular ejection fraction.

Keywords

Rho-kinase inhibitorFasudilDiastolic dysfunctionType 2 diabetes

Copyright information

© Springer Japan 2014

Authors and Affiliations

  • Rong Guo
    • 1
  • Yang Su
    • 1
  • Jing Yan
    • 2
  • Hui Sun
    • 1
  • Jiakang Wu
    • 1
  • Weijing Liu
    • 1
  • Yawei Xu
    • 1
  1. 1.Department of Cardiology, Shanghai Tenth People’s HospitalTongji University School of MedicineShanghaiChina
  2. 2.Department of Endocrinology, Shanghai Tenth People’s HospitalTongji University School of MedicineShanghaiChina