Heart and Vessels

, Volume 27, Issue 1, pp 106–109

A case of subacute thrombosis associated with clopidogrel resistance after implantation of a zotarolimus-eluting stent

Authors

    • Department of CardiologyInternational Goodwill Hospital
  • Atsushi Matsuda
    • Department of CardiologyInternational Goodwill Hospital
  • Manabu Nitta
    • Department of CardiologyInternational Goodwill Hospital
  • Keiko Yoshida
    • Department of CardiologyInternational Goodwill Hospital
  • Makoto Shimizu
    • Department of CardiologyInternational Goodwill Hospital
Case Report

DOI: 10.1007/s00380-011-0134-4

Cite this article as:
Arima, M., Matsuda, A., Nitta, M. et al. Heart Vessels (2012) 27: 106. doi:10.1007/s00380-011-0134-4

Abstract

A 73-year-old woman was admitted to our hospital with anterior acute myocardial infarction due to subacute thrombosis after coronary stenting with a zotarolimus-eluting stent (ZES), which is a newly developed drug-eluting stent that has been widely used since May 2009 in Japan. Five days before, she underwent implantation with a ZES in the left anterior descending artery due to stable angina pectoris. After stenting, the intravascular ultrasonography showed no malapposition from the proximal to the distal edge of the stent. She received aspirin 100 mg/day and clopidogrel 75 mg/day from 2 weeks before the stent was implanted. When we investigated the single nucleotide polymorphisms of CYP2C19 in this patient, both CYP2C19*2 and CYP2C19*3 were detected, and she was classified as a poor metabolizer. This report is the first to describe subacute stent thrombosis following the implantation of a newly developed ZES in a Japanese patient, which may be related to clopidogrel resistance.

Keywords

Clopidogrel resistanceAcute coronary syndromePercutaneous coronary interventionDrug-eluting stent

Copyright information

© Springer 2011