Heart and Vessels

, Volume 27, Issue 2, pp 186–192

Platelet and monocyte activity markers and mediators of inflammation in Takotsubo cardiomyopathy

  • Rainer Pirzer
  • Elif Elmas
  • Dariusch Haghi
  • Christiane Lippert
  • Stefan Kralev
  • Siegfried Lang
  • Martin Borggrefe
  • Thorsten Kälsch
Original Article

DOI: 10.1007/s00380-011-0132-6

Cite this article as:
Pirzer, R., Elmas, E., Haghi, D. et al. Heart Vessels (2012) 27: 186. doi:10.1007/s00380-011-0132-6

Abstract

Patients with Takotsubo cardiomyopathy (TC) often present with symptoms similar to those of myocardial infarction (MI). We analyzed blood concentrations of mediators of inflammation and platelet- and monocyte-activity markers in patients with TC and MI for significant differences. Clinical data of patients with TC (n = 16) and acute MI (n = 16) were obtained. Serial blood samples were taken at the time of hospital admission (t0), after 2–4 days (t1) and after 4–7 weeks (t2), respectively. Plasma concentrations of interleukin (IL)-6, IL-7, soluble CD40 ligand (sCD40L), and monocyte chemotactic protein 1 (MCP-1) were determined with an ELISA. Tissue factor binding on monocytes, platelet-activation marker CD62P, platelet CD40-ligand (CD40L), and platelet-monocyte aggregates were measured using flow cytometry. Expression of CD62P on platelets and IL-6 plasma levels were significantly lower in patients with TC compared to MI at the time of hospital admission. IL-7 plasma levels were significantly elevated in patients with TC compared to patients with MI at 2–4 days after hospital admission. No significant differences were observed concerning sCD40L and MCP-1 plasma levels, tissue factor binding on monocytes, CD40L expression on platelets, and platelet-monocyte aggregates at any point in time. Our results indicate that inflammatory mediators and platelet-activity markers contribute to the differences in the pathogenesis of MI and TC.

Keywords

Platelets Inflammation Takotsubo cardiomyopathy Stress 

Copyright information

© Springer 2011

Authors and Affiliations

  • Rainer Pirzer
    • 1
  • Elif Elmas
    • 1
  • Dariusch Haghi
    • 1
  • Christiane Lippert
    • 1
  • Stefan Kralev
    • 1
  • Siegfried Lang
    • 1
  • Martin Borggrefe
    • 1
  • Thorsten Kälsch
    • 1
  1. 1.1st Department of Medicine (Cardiology)University Medical Centre Mannheim, Medical Faculty Mannheim, University of HeidelbergMannheimGermany

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