Heart and Vessels

, Volume 24, Issue 5, pp 347–351

Clinical features of early recurrent myocardial infarction

Authors

  • Kenichi Sakakura
    • Division of Cardiovascular Medicine, Department of Integrated Medicine IJichi Medical University Saitama Medical Center
    • Division of Cardiovascular Medicine, Department of Integrated Medicine IJichi Medical University Saitama Medical Center
  • Junya Ako
    • Division of Cardiovascular MedicineStanford University School of Medicine
  • Nahoko Ikeda
    • Division of Cardiovascular Medicine, Department of Integrated Medicine IJichi Medical University Saitama Medical Center
  • Hiroshi Funayama
    • Division of Cardiovascular Medicine, Department of Integrated Medicine IJichi Medical University Saitama Medical Center
  • Taishi Hirahara
    • Division of Cardiovascular Medicine, Department of Integrated Medicine IJichi Medical University Saitama Medical Center
  • Hiroshi Wada
    • Division of Cardiovascular Medicine, Department of Integrated Medicine IJichi Medical University Saitama Medical Center
  • Yoshitaka Sugawara
    • Division of Cardiovascular Medicine, Department of Integrated Medicine IJichi Medical University Saitama Medical Center
  • Takanori Yasu
    • Division of Cardiovascular Medicine, Department of Integrated Medicine IJichi Medical University Saitama Medical Center
  • Masanobu Kawakami
    • Division of Cardiovascular Medicine, Department of Integrated Medicine IJichi Medical University Saitama Medical Center
  • Shin-ichi Momomura
    • Division of Cardiovascular Medicine, Department of Integrated Medicine IJichi Medical University Saitama Medical Center
Original Article

DOI: 10.1007/s00380-008-1133-y

Cite this article as:
Sakakura, K., Kubo, N., Ako, J. et al. Heart Vessels (2009) 24: 347. doi:10.1007/s00380-008-1133-y

Abstract

Recurrence of myocardial infarction, especially when occurring early after the prior one, carries a significant morbidity and mortality rate. The aim of this study was to investigate the characteristics of patients who experienced recurrence under secondary prevention therapy. Case record review identified myocardial infarction patients who had a history of previous myocardial infarction within 5 years. Hospital chart records, initial laboratory data, medications, and type of infarction were reviewed. Patients were divided into two groups according to the interval of recurrence: an early group (recurrence within 1 year), and a late group (recurrence after more than 1 year). A total of 89 patients were included in the analysis; 40 patients in the early group, and 49 patients in the late group. Mean age in the early group and late groups was 67.3 ± 11.9 and 59.4 ± 8.9, respectively (P = 0.001). Mean body mass index in the early and late groups was 22.1 ± 3.6 and 25.0 ± 3.3, respectively (P < 0.001). There were fewer current smokers in the early group (7.5% vs 44.9%, P < 0.001) and more stent thrombosis (17.5% vs 2%, P = 0.02), as compared with the late group. The in-hospital mortality rate tended to be higher in the early group (7.5% vs 0%, P = 0.09). Multiple logistic regression revealed that smoking status (odds ratio [OR] 0.09, 95% confidence interval [CI] 0.02−0.49, P = 0.005), HDL cholesterol level (5 mg/dl increase: OR 1.34, 95% CI 1.04−1.74, P = 0.03), and stent thrombosis (OR 35.59, 95% CI 2.13−595.49, P = 0.01) had significant associations with early recurrence. Early recurrence of myocardial infarction was associated with stent thrombosis, a higher HDL cholesterol level, and a lower frequency of smoking. Early recurrence had a trend toward higher mortality than late recurrence.

Key words

Myocardial infarctionRecurrenceSecondary prevention

Copyright information

© Springer Japan 2009