Journal of Comparative Physiology B

, Volume 174, Issue 8, pp 633–639

Fat-cell mass, serum leptin and adiponectin changes during weight gain and loss in yellow-bellied marmots (Marmota flaviventris)

Authors

    • Department of BiologyColorado State University
  • Heather Porst
    • Department of BiologyColorado State University
  • Aubrey Peiffer
    • Department of BiologyColorado State University
  • Susan F. Hudachek
    • Department of BiologyColorado State University
  • Chris Pittman
    • Department of BiologyColorado State University
  • Scott A.Summers
    • Department of BiochemistryColorado State University
  • Michael W. Rajala
    • Department of Cell BiologyAlbert Einstein College of Medicine
  • Philipp E. Scherer
    • Department of Cell BiologyAlbert Einstein College of Medicine
Original Paper

DOI: 10.1007/s00360-004-0454-0

Cite this article as:
Florant, G.L., Porst, H., Peiffer, A. et al. J Comp Physiol B (2004) 174: 633. doi:10.1007/s00360-004-0454-0

Abstract

Leptin and adiponectin are proteins produced and secreted from white adipose tissue and are important regulators of energy balance and insulin sensitivity. Seasonal changes in leptin and adiponectin have not been investigated in mammalian hibernators in relationship to changes in fat cell and fat mass. We sought to determine the relationship between serum leptin and adiponectin levels with seasonal changes in lipid mass. We collected serum and tissue samples from marmots (Marmota flaviventris) in different seasons while measuring changes in fat mass, including fat-cell size. We found that leptin is positively associated with increasing fat mass and fat-cell size, while adiponectin is negatively associated with increasing lipid mass. These findings are consistent with the putative roles of these adipokines: leptin increases with fat mass and is involved in enhancing lipid oxidation while adiponectin appears to be higher in summer when hepatic insulin sensitivity should be maintained since the animals are eating. Our data suggest that during autumn/winter animals have switched from a lipogenic condition to a lipolytic state, which may include leptin resistance.

Keywords

LeptinAdiponectinHibernationFatFasting

Copyright information

© Springer-Verlag 2004