Journal of Comparative Physiology A

, Volume 201, Issue 9, pp 911–920

Fine-scale topography in sensory systems: insights from Drosophila and vertebrates

Review

DOI: 10.1007/s00359-015-1022-7

Cite this article as:
Kaneko, T. & Ye, B. J Comp Physiol A (2015) 201: 911. doi:10.1007/s00359-015-1022-7

Abstract

To encode the positions of sensory stimuli, sensory circuits form topographic maps in the central nervous system through specific point-to-point connections between pre- and postsynaptic neurons. In vertebrate visual systems, the establishment of topographic maps involves the formation of a coarse topography followed by that of fine-scale topography that distinguishes the axon terminals of neighboring neurons. It is known that intrinsic differences in the form of broad gradients of guidance molecules instruct coarse topography while neuronal activity is required for fine-scale topography. On the other hand, studies in the Drosophila visual system have shown that intrinsic differences in cell adhesion among the axon terminals of neighboring neurons instruct the fine-scale topography. Recent studies on activity-dependent topography in the Drosophila somatosensory system have revealed a role of neuronal activity in creating molecular differences among sensory neurons for establishing fine-scale topography, implicating a conserved principle. Here we review the findings in both Drosophila and vertebrates and propose an integrated model for fine-scale topography.

Keywords

Fine-scale topography Sensory systems Drosophila Activity-dependent projections Synaptic connectivity 

Abbreviations

C4da neurons

Class IV dendritic arborization neurons

RGC

Retinal ganglion cell

VNC

Ventral nerve cord

Fmi

Flamingo

Ncad

N-cadherin

β2KO

Mouse knockout of β2 subunit of the nicotinic acetylcholine receptor

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Life Sciences Institute and Department of Cell and Developmental BiologyUniversity of MichiganAnn ArborUSA

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