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Prostatic artery embolization for the treatment of symptomatic benign prostatic hyperplasia in men ≥75 years: a prospective single-center study

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Abstract

Purpose

To compare the safety and efficacy of PAE for the treatment of benign prostatic hyperplasia (BPH) in men ≥75 years, who we defined as elderly, to those <75 years.

Methods

A total of 157 patients diagnosed with lower urinary tract symptoms (LUTS) due to BPH underwent PAE. Group A (n = 52) included patients ≥75 years, and group B (n = 105) included patients <75 years. Follow-up was performed using the International Prostate Symptoms Score (IPSS), quality of life (QoL), peak urinary flow rate (Q max), post-void residual volume (PVR), the International Index of Erectile Function short form (IIEF-5), prostatic-specific antigen (PSA), and prostate volume (PV), at 1, 3, 6, and every 6 months thereafter.

Results

More coexistent systemic diseases were identified in group A than in group B (P < 0.05). Technical success rate of PAE was 90.4 % in group A and 95.2 % in group B (P = 0.06). A total of 147 patients had completed the follow-up with a mean of 20 months. Compared with the baseline, there were significant improvements in IPSS, QoL, Q max, PV, PVR, and PSA in both groups after PAE. There were no significant differences in the changes of IPSS, Q max, PVR, PSA, and IIEF-5 between groups after PAE. No major complications were noted.

Conclusion

PAE could be used as an effective, safe, and well tolerable method in the treatment of elderly symptomatic BPH patients, similarly to younger patients, and it may play an important role in patients in whom medical therapy has failed, who are at high surgical and anesthetic risk or who refuse the standard surgical therapy.

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Acknowledgments

This work was supported by grants from the National Scientific Foundation Committee of China (No. 81471769), the central health research project (2013BJ09), and Chinese PLA Scientific Foundation of the Twelve-Five Programme (BWS11J028).

Funding

This work was supported by grants from the National Scientific Foundation Committee of China (No. 81471769), the central health research project (2013BJ09), and Chinese PLA Scientific Foundation of the Twelve-Five Programme (BWS11J028).

Authors’ contributions

Wang MQ and Wang Y involved in project development and wrote the manuscript. Wang Y and Yuan K involved in data collection. Zhang GD and Duan F involved in the literature research. Wang MQ and Yan JY involved in data analysis and statistical analysis. Wang MQ and Kai Li reviewed the manuscript. All authors read and approved the final manuscript.

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    Authors and Affiliations

    1. Department of Interventional Radiology, Chinese PLA General Hospital, Beijing, 100853, People’s Republic of China

      Mao Qiang Wang, Yan Wang, Jie Yu Yan, Kai Yuan, Guo Dong Zhang, Feng Duan & Kai Li

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    1. Mao Qiang Wang
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    2. Yan Wang
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    Correspondence to Mao Qiang Wang.

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    All authors have declared that no competing interests exist.

    Ethical statement

    This study was approved by the hospital ethics committee and has been performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments.

    Additional information

    M. Q. Wang is the article guarantor. M. Q. Wang, Y. Wang, and J. Y. Yan contributed equally to this work and are joint first authors on this article.

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    Cite this article

    Wang, M.Q., Wang, Y., Yan, J.Y. et al. Prostatic artery embolization for the treatment of symptomatic benign prostatic hyperplasia in men ≥75 years: a prospective single-center study. World J Urol 34, 1275–1283 (2016). https://doi.org/10.1007/s00345-016-1771-0

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