Application of the 2013 American Urological Association early detection of prostate cancer guideline: Who will we miss?
- Gregory B. AuffenbergAffiliated withDepartment of Urology, Northwestern University Feinberg School of Medicine
- , Joshua J. MeeksAffiliated withDepartment of Urology, Northwestern University Feinberg School of Medicine Email author
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The American Urological Association (AUA) published new prostate cancer (CaP) screening guidelines in 2013. We apply the guidelines to a retrospective cohort to compare tumor characteristics of those no longer recommended for screening with those who remain screening candidates.
We identified cases of screening detected CaP (stage cT1c) in the Surveillance Epidemiology and End Results database from October 2005 to December 2010. The 2013 AUA Guidelines were retrospectively applied to the cohort. Men were categorized into three groups for comparison based on whether or not they would now be recommended for CaP screening (Unscreened, Young Unscreened, and Screened). We compared clinical and pathological characteristics of CaP across study groups.
A total of 142,382 men were identified. Screening would no longer be recommended for 40,160. Those no longer recommended for screening had higher median PSA (6.4 vs. 5.8 ng/mL, p < 0.01), more Gleason 7 and ≥8 CaP on prostate biopsy (36.4 vs. 34.8 %, p < 0.001; 12.4 vs. 9.2 %, p < 0.001, respectively) and slightly more Gleason ≥8 CaP (9.0 vs. 7.5 %, p = 0.03), and T3 tumors (17.3 vs. 16.5 %, p = 0.01) at prostatectomy. Nodal and distant metastasis rates were clinically equivalent among men screened and unscreened. Subgroup analysis of young patients (40–54 years old) no longer recommended for screening identified intermediate or high-risk Gleason scores at prostatectomy 57.6 % of the time.
Features of CaP in men no longer recommended for routine screening are largely equivalent to if not worse than those in screened men.
KeywordsProstate cancer Screening Guidelines Prostate-specific antigen
- Application of the 2013 American Urological Association early detection of prostate cancer guideline: Who will we miss?
World Journal of Urology
Volume 32, Issue 4 , pp 959-964
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- Springer Berlin Heidelberg
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- Prostate cancer
- Prostate-specific antigen
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