Original Article

World Journal of Urology

, Volume 31, Issue 6, pp 1389-1394

First online:

Prevalence of the human papillomavirus (HPV) expression of the inner prepuce in asymptomatic boys and men

  • Gerald KlinglmairAffiliated withDepartment of Urology, Medical University of Innsbruck
  • , Renate PichlerAffiliated withDepartment of Urology, Medical University of Innsbruck
  • , Bettina ZelgerAffiliated withDepartment of Pathology, Medical University of Innsbruck
  • , Hasan Serkan DoganAffiliated withDepartment of Urology, Faculty of Medicine, Uludag University
  • , Tanja BeckerAffiliated withDepartment of Pediatric Urology, St. Vincent’s Hospital
  • , Johannes EsterbauerAffiliated withDepartment of Urology, St. Vincent’s Hospital
  • , Markus RiccabonaAffiliated withDepartment of Pediatric Urology, St. Vincent’s Hospital
  • , Wolfgang LoidlAffiliated withDepartment of Urology, St. Vincent’s Hospital
  • , Wolfgang HorningerAffiliated withDepartment of Urology, Medical University of Innsbruck

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Abstract

Objective

To investigate the prevalence of high-risk (HR) and low-risk (LR) human papillomavirus (HPV) in prepuces of boys and men without any HPV related lesions.

Patients and methods

Between 2009 and 2011, a total collective of 250 boys and men were investigated in this prospective study. The samples were subdivided into 3 groups regarding their age, consisting of 125 (50 %) children (0–10 years), 38 (15.2 %) adolescents (11–20 years) and 87 (34.8 %) adults (>20 years). In situ hybridization (ISH) was performed to detect HR and LR virus types within the epithelium, followed by microscopic interpretation and determination between episomal and integrative signal pattern.

Results

Our results revealed high levels of HPV concentration (HR and LR) in all age groups: HR versus LR positivity was seen in 45.5 versus 35 % (children), 60.6 versus 63.6 % (adolescents) and 58.3 versus 48.6 % (adults). The topmost rate of HR (59.8 %)- and LR (50.6 %)-positive probes was found in the group with high estimated sexual activity (>14 years).

Conclusion

Concerning the high prevalence of male HPV infection even in children, indicating non-sexual transmission pathways, inclusion of boys in the vaccination program seems to be required reducing their burden of HPV related disease.

Keywords

HPV Circumcision STD Prepuce Vaccination