World Journal of Urology

, Volume 31, Issue 4, pp 861–867

Epidemiologic profile, sexual history, pathologic features, and human papillomavirus status of 103 patients with penile carcinoma

  • Alcides Chaux
  • George J. Netto
  • Ingrid M. Rodríguez
  • José E. Barreto
  • Judith Oertell
  • Sandra Ocampos
  • Hugo Boggino
  • Ricardo Codas
  • F. Xavier Bosch
  • Silvia de Sanjose
  • Nubia Muñoz
  • Allan Hildesheim
  • Antonio L. Cubilla
Original Article

DOI: 10.1007/s00345-011-0802-0

Cite this article as:
Chaux, A., Netto, G.J., Rodríguez, I.M. et al. World J Urol (2013) 31: 861. doi:10.1007/s00345-011-0802-0

Abstract

Purpose

The incidence of penile cancer is four times higher in Paraguay than in the United States or Europe. There are no adequate scientific explanations for this geographical variation. The goal of this study was to evaluate the interplay among risk factors, morphology of the primary tumor, and HPV status.

Methods

Information on socioeconomic status, education level, habits, and sexual history was obtained in 103 Paraguayan patients with penile cancer. All patients were then treated by surgery, and specimens were evaluated histopathologically.

Results

Patients usually dwelled in rural/suburban areas (82%), lived in poverty (75%), had a low education level (91%), and were heavy smokers (76%). Phimosis (57%), moderate/poor hygienic habits (90%), and history of sexually transmitted diseases (74%) were frequently found. Patients with >10 lifetime female partners had an odds ratio of 3.8 (95% CI 1.1, 12.6; P-trend = .03) for presenting HPV-positive tumors when compared to patients with <6 partners. However, this trend was not significant when the number of sexual partners was adjusted for age of first coitus and antecedents of sexually transmitted diseases. HPV-related tumors (found in 36% of the samples) were characterized by a warty and/or basaloid morphology and high histological grade in most cases.

Conclusions

In our series, patients with penile cancer presented a distinctive epidemiologic and pathologic profile. These data might help explaining the geographical differences in incidence and aid in the design of strategies for cancer control in Paraguay.

Keywords

Penile cancerHuman papillomavirusCircumcisionPhimosisLichen sclerosusRisk factors

Copyright information

© Springer-Verlag 2011

Authors and Affiliations

  • Alcides Chaux
    • 1
    • 2
  • George J. Netto
    • 2
  • Ingrid M. Rodríguez
    • 1
  • José E. Barreto
    • 1
  • Judith Oertell
    • 1
  • Sandra Ocampos
    • 1
  • Hugo Boggino
    • 1
  • Ricardo Codas
    • 1
  • F. Xavier Bosch
    • 3
  • Silvia de Sanjose
    • 3
    • 4
  • Nubia Muñoz
    • 3
  • Allan Hildesheim
    • 5
  • Antonio L. Cubilla
    • 1
  1. 1.Instituto de Patología e InvestigaciónAsunciónParaguay
  2. 2.Department of PathologyThe Johns Hopkins University School of MedicineBaltimoreUSA
  3. 3.Institut Català d’OncologiaBarcelonaSpain
  4. 4.CIBER Epidemiologia y Salud PúblicaBarcelonaSpain
  5. 5.Infections and Immunoepidemiology Branch, Division of Cancer Epidemiology and GeneticsNational Cancer InstituteBethesdaUSA