World Journal of Urology

, Volume 30, Issue 4, pp 495–503

Novel options for the treatment of castration-resistant prostate cancer

  • Carsten-H. Ohlmann
  • Axel S. Merseburger
  • Henrik Suttmann
  • David Schilling
  • Lutz Trojan
  • Carsten Kempkensteffen
  • Stefan Corvin
  • Michael J. Mathers
  • Patrick J. Bastian
Invited Review

DOI: 10.1007/s00345-011-0796-7

Cite this article as:
Ohlmann, C., Merseburger, A.S., Suttmann, H. et al. World J Urol (2012) 30: 495. doi:10.1007/s00345-011-0796-7

Abstract

Docetaxel had been the only treatment of castration-resistant prostate cancer (CRPC) that demonstrated a survival benefit for the patients. After its approval, no considerable progress has been made for several years until cabazitaxel and abiraterone acetate demonstrated a significant survival benefit in phase III clinical trials. Apart from that several other new drugs appeared including inhibitors of the androgen receptor (MDV3100), endothelin receptor antagonists (atrasentan, zibotentan), bone-targeted drugs (denosumab, Alpharadin) and immunotherapies (sipuleucel-T) capable of improving the prognosis of patients with CRPC. Here, we review the most recent advances in the treatment of CRPC and highlight the most promising new agents currently being investigated in clinical trials.

Keywords

Castration-resistant prostate cancerAbirateroneMDV3100ZibotentanDenosumabAlpharadin

Copyright information

© Springer-Verlag 2011

Authors and Affiliations

  • Carsten-H. Ohlmann
    • 1
  • Axel S. Merseburger
    • 2
  • Henrik Suttmann
    • 3
  • David Schilling
    • 4
  • Lutz Trojan
    • 5
  • Carsten Kempkensteffen
    • 6
  • Stefan Corvin
    • 7
  • Michael J. Mathers
    • 8
  • Patrick J. Bastian
    • 9
  1. 1.Department of UrologySaarland UniversityHomburg/SaarGermany
  2. 2.Department of UrologyHannover Medical SchoolHannoverGermany
  3. 3.Urologikum HamburgHamburgGermany
  4. 4.Department of UrologyEberhard-Karls-UniversityTuebingenGermany
  5. 5.Department of Urology, Medical Faculty MannheimUniversity of HeidelbergMannheimGermany
  6. 6.Department of UrologyCharité, University Medicine BerlinBerlinGermany
  7. 7.Fachzentrum für Urologie EggenfeldenEggenfeldenGermany
  8. 8.PandaMED RemscheidRemscheidGermany
  9. 9.Urologische Klinik und PoliklinikKlinikum der Universität-Campus Großhadern, Ludwig-Maximilians-Universität MünchenMünchenGermany