World Journal of Urology

, Volume 30, Issue 4, pp 525–531

Kidney-specific cadherin correlates with the ontogenetic origin of renal cell carcinoma subtypes: an indicator of a malignant potential?

  • M. Horstmann
  • L. M. Geiger
  • U. Vogel
  • H. Schmid
  • J. Hennenlotter
  • U. Kuehs
  • A. S. Merseburger
  • S. Kruck
  • A. Stenzl
  • J. Bedke
Original Article

DOI: 10.1007/s00345-011-0763-3

Cite this article as:
Horstmann, M., Geiger, L.M., Vogel, U. et al. World J Urol (2012) 30: 525. doi:10.1007/s00345-011-0763-3

Abstract

Introduction and objectives

To evaluate retrospectively kidney-specific cadherin (Ksp-cad) expression in renal cell carcinoma (RCC) subtypes and oncocytoma in correlation with its ontogenetic origin of distal and proximal tubules and to correlate Ksp-cad expression with tumour characteristics.

Materials and methods

Membranous and cytoplasmic expression of Ksp-cad was determined in 40 clear cell (ccRCC), 25 papillary (pRCC), 19 chromophobe carcinomas (chRCC), 27 oncocytomas (oncocytomas) (n = 111) and 32 benign kidney parenchyma specimens separated in distal tubules (DT) and proximal tubules (PT) by immunohistochemistry using tissue microarray technique. Staining intensity was quantified as a score ranging from 0 to 12. Comparison of data and correlation with tumour characteristics were done by Wilcoxon/Kruskal–Wallis tests (post hoc Tukey–Kramer analysis).

Results

In benign renal tissue, membranous and cytoplasmic expression of Ksp-cad in the DT was significantly higher than that in the PT (12.0 ± 0 vs. 5.2 ± 0.3 and 6.3 ± 0.5 vs. 0.0 ± 0.0, respectively; (P < 0.05)). Membranous KSP-cad expression was significantly higher in chRCC (5.2 ± 0.8) and oncocytomas (3.7 ± 0.4) than that in ccRCC (0.8 ± 0.2) and pRCC (1.4 ± 0.4; P < 0.05), while expression between oncocytomas and chRCC did not differ significantly. In RCC, Ksp-cad expression was significantly associated with higher T stage and the occurrence of synchronous metastasis (P < 0.05). Higher N stages and grading tended to correlate with a lower Ksp-cad expression.

Conclusions

In this cohort, the origin of tumour subtypes—chRCC and oncocytomas develop from DT and ccRCC and pRCC from PT cells—is mirrored by the respective Ksp-cad expression. This raises the question whether DT-derived tumours have a less malignant potential than PT-derived tumours.

Keywords

Renal tumours Kidney-specific cadherin Oncocytoma Immunohistochemistry 

Supplementary material

345_2011_763_MOESM1_ESM.doc (40 kb)
Supplementary material 1 (DOC 40 kb)

Copyright information

© Springer-Verlag 2011

Authors and Affiliations

  • M. Horstmann
    • 1
    • 2
  • L. M. Geiger
    • 1
  • U. Vogel
    • 4
  • H. Schmid
    • 5
  • J. Hennenlotter
    • 1
  • U. Kuehs
    • 1
  • A. S. Merseburger
    • 3
  • S. Kruck
    • 1
  • A. Stenzl
    • 1
  • J. Bedke
    • 1
  1. 1.Department of UrologyEberhard Karls University TuebingenTuebingenGermany
  2. 2.Department of UrologyKantonsspital WinterthurWinterthurSwitzerland
  3. 3.Department of Urology and Urologic OncologyHannover Medical SchoolHannoverGermany
  4. 4.Institute of PathologyEberhard Karls University TuebingenTuebingenGermany
  5. 5.Interfaculty Institute for BiochemistryUniversity of TuebingenTuebingenGermany

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