World Journal of Urology

, Volume 30, Issue 1, pp 51–57

Update on biofilm infections in the urinary tract

  • Peter Tenke
  • Béla Köves
  • Károly Nagy
  • Scott J. Hultgren
  • Werner Mendling
  • Björn Wullt
  • Magnus Grabe
  • Florian M. E. Wagenlehner
  • Mete Cek
  • Robert Pickard
  • Henry Botto
  • Kurt G. Naber
  • Truls E. Bjerklund Johansen
Topic paper

DOI: 10.1007/s00345-011-0689-9

Cite this article as:
Tenke, P., Köves, B., Nagy, K. et al. World J Urol (2012) 30: 51. doi:10.1007/s00345-011-0689-9

Abstract

Purpose

Biofilm infections have a major role in implants or devices placed in the human body. As part of the endourological development, a great variety of foreign bodies have been designed, and with the increasing number of biomaterial devices used in urology, biofilm formation and device infection is an issue of growing importance.

Methods

A literature search was performed in the Medline database regarding biofilm formation and the role of biofilms in urogenital infections using the following items in different combinations: “biofilm,” “urinary tract infection,” “bacteriuria,” “catheter,” “stent,” and “encrustation.” The studies were graded using the Oxford Centre for Evidence-based Medicine classification.

Results

The authors present an update on the mechanism of biofilm formation in the urinary tract with special emphasis on the role of biofilms in lower and upper urinary tract infections, as well as on biofilm formation on foreign bodies, such as catheters, ureteral stents, stones, implants, and artificial urinary sphincters. The authors also summarize the different methods developed to prevent biofilm formation on urinary foreign bodies.

Conclusions

Several different approaches are being investigated for preventing biofilm formation, and some promising results have been obtained. However, an ideal method has not been developed. Future researches have to aim at identifying effective mechanisms for controlling biofilm formation and to develop antimicrobial agents effective against bacteria in biofilms.

Keywords

Biofilm Urinary tract infection Catheter Encrustation 

Copyright information

© Springer-Verlag 2011

Authors and Affiliations

  • Peter Tenke
    • 1
  • Béla Köves
    • 1
  • Károly Nagy
    • 1
  • Scott J. Hultgren
    • 2
  • Werner Mendling
    • 3
  • Björn Wullt
    • 4
  • Magnus Grabe
    • 4
  • Florian M. E. Wagenlehner
    • 5
  • Mete Cek
    • 6
  • Robert Pickard
    • 7
  • Henry Botto
    • 8
  • Kurt G. Naber
    • 9
  • Truls E. Bjerklund Johansen
    • 10
  1. 1.Department of UrologySouth-Pest HospitalBudapestHungary
  2. 2.Department of Molecular MicrobiologyWashington University Medical SchoolSt. LouisUSA
  3. 3.Clinics of Obstetrics and GynecologyBerlinGermany
  4. 4.Department of Urology, Malmö University HospitalLund UniversityMalmöSweden
  5. 5.Clinic for Urology, Pediatric Urology and AndrologyJustus-Liebig-UniversityGiessenGermany
  6. 6.Trakya Medical Faculty, Department of UrologyEdirneTurkey
  7. 7.Department of UrologyFreeman HospitalNewcastle Upon TyneUK
  8. 8.Service d’urologieHôpital FochSuresnesFrance
  9. 9.Technical University of MunichMunichGermany
  10. 10.Department of UrologyÅrhus University HospitalÅrhus NDenmark

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