World Journal of Urology

, Volume 27, Issue 5, pp 653–658

Oncologic outcome after radical prostatectomy in men with PSA values above 20 ng/ml: a monocentric experience

  • Kien Nguyen
  • Stephanie Eltz
  • Sarah J. Drouin
  • Eva Comperat
  • François Audenet
  • Raphaele Renard-Penna
  • Marc-Olivier Bitker
  • Emmanuel Chartier-Kastler
  • François Richard
  • Olivier Cussenot
  • Morgan Rouprêt
Original Article

DOI: 10.1007/s00345-009-0419-8

Cite this article as:
Nguyen, K., Eltz, S., Drouin, S.J. et al. World J Urol (2009) 27: 653. doi:10.1007/s00345-009-0419-8

Abstract

Objective

To assess the cancer control afforded by radical prostatectomy (RP) in patients with prostate-specific antigen (PSA) values above 20 ng/ml.

Methods

We performed a retrospective review of prostate cancer patients who had initial PSA values above 20 ng/ml and were treated with surgery between 1995 and 2006. Biochemical recurrence was defined as a single rise in PSA levels over 0.2 ng/ml after surgery.

Results

Overall, 41 patients were included. The mean age was 62 ± 6.43 years. The mean PSA was 27.39 ± 13.57 ng/ml (range 20.3–80). After pathological analysis, prostate cancer was organ-confined in 21 cases (51.2%) and locally advanced in 20 cases (48.8%). Positive surgical margins were detected in 36.5% of cases (n = 15). Five patients had lymph node involvement (12%). The mean prostate volume was 58 ± 28.9 cc. The mean length of follow-up after surgery was 94 ± 37 months. Median time to biochemical recurrence was 44.6 ± 22 months. The 5-year PSA-free survival rate was 53%. Through univariate analysis, the pathologic stage (p = 0.016), biopsy and pathological Gleason scores (p = 0.013; p = 0.02) and positive margin (p = 0.04) were associated with recurrence. Overall, 24 patients (58.5%) experienced a biochemical recurrence. Only margin status and pathological Gleason were significant in multivariate analysis (p < 0.05).

Conclusion

RP can be recommended as a viable primary treatment option in selected cases of the high-risk cohort of patients with pre-operative PSA values above 20 ng/ml. However, the modalities of adjuvant treatments following RP remain to be defined in patients who are likely to evolve unfavourably.

Keywords

Prostatic neoplasmsProstate-specific antigenOutcomeBiochemical recurrenceRadical prostatectomy

Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  • Kien Nguyen
    • 1
  • Stephanie Eltz
    • 1
  • Sarah J. Drouin
    • 1
  • Eva Comperat
    • 2
    • 4
  • François Audenet
    • 1
  • Raphaele Renard-Penna
    • 3
  • Marc-Olivier Bitker
    • 1
  • Emmanuel Chartier-Kastler
    • 1
  • François Richard
    • 1
  • Olivier Cussenot
    • 4
  • Morgan Rouprêt
    • 1
    • 4
  1. 1.Department of Urology of Pitié-Salpétrière Hospital, GHU Est, Assistance-Publique Hôpitaux de Paris, Faculté de Médecine Pierre et Marie CurieUniversity Paris VIParisFrance
  2. 2.Department of Pathology of Pitié-Salpétrière Hospital, GHU Est, Assistance-Publique Hôpitaux de Paris, Faculté de Médecine Pierre et Marie CurieUniversity Paris VIParisFrance
  3. 3.Department of Radiology of Pitié-Salpétrière Hospital, GHU Est, Assistance-Publique Hôpitaux de Paris, Faculté de Médecine Pierre et Marie CurieUniversity Paris VIParisFrance
  4. 4.CeRePP group “Centre d’Etudes et de Recherche sur les Pathologies Prostatiques”ParisFrance