World Journal of Urology

, Volume 27, Issue 3, pp 353–361

Experimental animal model and RNA interference: a promising association for bladder cancer research

  • Leonardo Oliveira Reis
  • Tiago Campos Pereira
  • Wagner José Favaro
  • Valéria Helena Alves Cagnon
  • Iscia Lopes-Cendes
  • Ubirajara Ferreira
Review

DOI: 10.1007/s00345-009-0374-4

Cite this article as:
Reis, L.O., Pereira, T.C., Favaro, W.J. et al. World J Urol (2009) 27: 353. doi:10.1007/s00345-009-0374-4

Abstract

Animal models are at the centre of laboratory bladder cancer (BC) research and at the same time, the bridge to the clinic. A new and very promising therapeutical approach is to silence abnormally up-regulated genes in cancer, through small interfering RNA (siRNA) molecules. Therapeutic use and success of siRNAs will largely depend on their efficient and safe in vivo delivery and on avoiding accidental off-target effects. Intravesical siRNA is a strategy which may be the best deliver option to surperficial BC like intravesical immunotherapy. Its direct action might allow a continuous intracellular exposure to effective siRNA concentrations. While the procedure of transurethral siRNA administration is promising for BC research allowing detection of new targets in BC therapy, the optimal intravesical carrier and the best target(s) to siRNA are to be determined.

Keywords

Experimental bladder cancer Animal model RNA interference Delivery 

Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  • Leonardo Oliveira Reis
    • 1
  • Tiago Campos Pereira
    • 2
  • Wagner José Favaro
    • 3
  • Valéria Helena Alves Cagnon
    • 3
  • Iscia Lopes-Cendes
    • 2
  • Ubirajara Ferreira
    • 1
  1. 1.Department of Urology, Faculty of Medical SciencesUniversity of Campinas, UNICAMPCampinasBrazil
  2. 2.Department of Medical Genetics, Faculty of Medical SciencesUniversity of Campinas, UNICAMPCampinasBrazil
  3. 3.Department of Anatomy, Institute of BiologyUniversity of Campinas, UNICAMPCampinasBrazil

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