, Volume 27, Issue 5, pp 619-625
Date: 21 Feb 2009

[11 C]choline PET/CT in prostate cancer patients with biochemical recurrence after radical prostatectomy

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Abstract

Objective

To evaluate [11C]choline positron emission tomography/computed tomography ([11C]choline PET/CT) for the detection of a biochemical recurrence of prostate cancer after radical prostatectomy.

Methods

Retrospective analysis of [11C]choline PET/CT performed in 41 consecutive prostate cancer patients with a rising PSA. The mean time to biochemical relapse was 24 months. PSA levels were determined at time of examination, and patients received either a targeted biopsy or surgery. Histopathology reports served as reference for the evaluation of the [11C]choline PET/CT findings.

Results

Mean PSA in [11C]choline PET/CT positive patients was 3.1 ng/ml (median 2.2 ng/ml, range 0.5–11.6 ng/ml) and 0.86 ng/ml in [11C]choline PET/CT negative patients (median 0.83 ng/ml, range 0.41–1.40 ng/ml). Six of 12 patients with PSA < 1.5 ng/ml [11C]choline PET/CT revealed a pathological uptake. Histopathology was positive in 6/12 patients in this group. At PSA levels ranging from 1.5 to 2.5 ng/ml all [11C]choline PET/CT were positive (n = 16), a positive histology was found in 12/16 patients (75%) and at PSA 2.5–5 ng/ml [11C]choline PET/CT was positive in 8/8 patients, confirmed by histology in 7/8 patients. Finally, at PSA higher than 5 ng/ml [11C]choline PET/CT identified 5/5 patients positive all confirmed by histology. The sensitivity of [11C]choline PET/CT for the detection of recurrence at PSA < 2.5 ng/ml was 89% with a positive predictive value of 72%.

Conclusion

[11C]choline PET/CT is useful for re-staging of prostate cancer in patients with rising PSA even at levels below 1.5 ng/ml. Our study confirms results from other published studies on [11C]choline PET/CT in prostate cancer relapse.