World Journal of Urology

, 27:619

[11C]choline PET/CT in prostate cancer patients with biochemical recurrence after radical prostatectomy

  • Ludwig Rinnab
  • Joerg Simon
  • Richard E. Hautmann
  • M. V. Cronauer
  • Kathrin Hohl
  • Andreas K. Buck
  • Sven N. Reske
  • Felix M. Mottaghy
Original Article

DOI: 10.1007/s00345-009-0371-7

Cite this article as:
Rinnab, L., Simon, J., Hautmann, R.E. et al. World J Urol (2009) 27: 619. doi:10.1007/s00345-009-0371-7

Abstract

Objective

To evaluate [11C]choline positron emission tomography/computed tomography ([11C]choline PET/CT) for the detection of a biochemical recurrence of prostate cancer after radical prostatectomy.

Methods

Retrospective analysis of [11C]choline PET/CT performed in 41 consecutive prostate cancer patients with a rising PSA. The mean time to biochemical relapse was 24 months. PSA levels were determined at time of examination, and patients received either a targeted biopsy or surgery. Histopathology reports served as reference for the evaluation of the [11C]choline PET/CT findings.

Results

Mean PSA in [11C]choline PET/CT positive patients was 3.1 ng/ml (median 2.2 ng/ml, range 0.5–11.6 ng/ml) and 0.86 ng/ml in [11C]choline PET/CT negative patients (median 0.83 ng/ml, range 0.41–1.40 ng/ml). Six of 12 patients with PSA < 1.5 ng/ml [11C]choline PET/CT revealed a pathological uptake. Histopathology was positive in 6/12 patients in this group. At PSA levels ranging from 1.5 to 2.5 ng/ml all [11C]choline PET/CT were positive (n = 16), a positive histology was found in 12/16 patients (75%) and at PSA 2.5–5 ng/ml [11C]choline PET/CT was positive in 8/8 patients, confirmed by histology in 7/8 patients. Finally, at PSA higher than 5 ng/ml [11C]choline PET/CT identified 5/5 patients positive all confirmed by histology. The sensitivity of [11C]choline PET/CT for the detection of recurrence at PSA < 2.5 ng/ml was 89% with a positive predictive value of 72%.

Conclusion

[11C]choline PET/CT is useful for re-staging of prostate cancer in patients with rising PSA even at levels below 1.5 ng/ml. Our study confirms results from other published studies on [11C]choline PET/CT in prostate cancer relapse.

Keywords

11C-choline PET/CT Prostate cancer Radical prostatectomy Restaging Prostate specific antigen Rising PSA 

Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  • Ludwig Rinnab
    • 1
  • Joerg Simon
    • 1
  • Richard E. Hautmann
    • 1
  • M. V. Cronauer
    • 1
  • Kathrin Hohl
    • 2
  • Andreas K. Buck
    • 3
  • Sven N. Reske
    • 3
  • Felix M. Mottaghy
    • 3
    • 4
    • 5
  1. 1.Department of UrologyUniversity of UlmUlmGermany
  2. 2.Department of Biometry and Medical DocumentationUniversity of UlmUlmGermany
  3. 3.Department of Nuclear MedicineUniversity of UlmUlmGermany
  4. 4.Department of Nuclear MedicineUniversity Hospital of KU LeuvenLeuvenBelgium
  5. 5.Department of Nuclear MedicineUniversity Hospital Gasthuisberg, KU LeuvenLeuvenBelgium

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