World Journal of Urology

, 27:117

Protective effect of trapidil on long-term histologic damage in a rat model of testicular ischemia-reperfusion injury

Authors

    • Department of UrologyUniversity of Mersin School of Medicine
  • Deniz Acar
    • Department of UrologyUniversity of Mersin School of Medicine
  • Selahittin Cayan
    • Department of UrologyUniversity of Mersin School of Medicine
  • Savas Aktas
    • Department of Histology/EmbryologyUniversity of Mersin School of Medicine
  • Ahmet Tunckiran
    • Department of UrologyUniversity of Mersin School of Medicine
Original Article

DOI: 10.1007/s00345-008-0323-7

Cite this article as:
Bozlu, M., Acar, D., Cayan, S. et al. World J Urol (2009) 27: 117. doi:10.1007/s00345-008-0323-7

Abstract

Objectives

Trapidil is an antianginal compound with a broad spectrum of pharmacological activities. In recent years, it has been used successfully to decrease ischemia-reperfusion injury in several organ systems. We evaluated the effect of trapidil on the long-term histologic damage in testicular ischemia-reperfusion injury.

Methods

Adult male Wistar rats were divided into three groups of six rats each. One group underwent 2 h of testicular torsion; one received pretreatment with trapidil before detorsion; and one group underwent sham operation. All rats underwent bilateral orchiectomy 60 days after the experiment. The mean seminiferous tubular diameter, germinal epithelial cell thickness, and mean testicular biopsy score were determined by histological examination of each testis.

Results

Testicular torsion–detorsion caused a significant decrease in the mean seminiferous tubular diameter, germinal epithelial cell thickness, and mean testicular biopsy score in the ipsilateral testes, but not in the contralateral testes. The animals treated with trapidil had a significant increase in these histological parameters as compared to the torsion–detorsion group.

Conclusion

Trapidil administration before reperfusion may have the potential to decrease the long-term histologic damage that occurs after experimental testicular torsion. Trapidil is used as an antianginal drug and additional clinical studies are required to elucidate the protective role of trapidil in patients with testicular torsion.

Keywords

TestisReperfusion injuryTrapidilRats

Copyright information

© Springer-Verlag 2008