Applied Physics B

, Volume 74, Issue 1, pp 95–99

Detection of biogenic CO production above vascular cell cultures using a near-room- temperature QC-DFB laser

Authors

  • A.A. Kosterev
    • Rice Quantum Institute, Rice University, Houston, TX 77 251-1892, USA
  • F.K. Tittel
    • Rice Quantum Institute, Rice University, Houston, TX 77 251-1892, USA
  • W. Durante
    • Departments of Medicine and Pharmacology, Baylor College of Medicine, Houston, TX 77 030, USA
  • M. Allen
    • Physical Sciences Inc., 20 New England Business Center, Andover, MA 01810, USA
  • R. Köhler
    • Bell Laboratories, Lucent Technologies, 600 Mountain Avenue, Murray Hill, NJ 07974, USA
  • C. Gmachl
    • Bell Laboratories, Lucent Technologies, 600 Mountain Avenue, Murray Hill, NJ 07974, USA
  • F. Capasso
    • Bell Laboratories, Lucent Technologies, 600 Mountain Avenue, Murray Hill, NJ 07974, USA
  • D.L. Sivco
    • Bell Laboratories, Lucent Technologies, 600 Mountain Avenue, Murray Hill, NJ 07974, USA
  • A.Y. Cho
    • Bell Laboratories, Lucent Technologies, 600 Mountain Avenue, Murray Hill, NJ 07974, USA

DOI: 10.1007/s003400100766

Cite this article as:
Kosterev, A., Tittel, F., Durante, W. et al. Appl Phys B (2002) 74: 95. doi:10.1007/s003400100766

Abstract.

We report the first application of pulsed, near-room-temperature quantum cascade laser technology to the continuous detection of biogenic CO production rates above viable cultures of vascular smooth muscle cells. A computer-controlled sequence of measurements over a 9-h period was obtained, resulting in a minimum detectable CO production of 20 ppb in a 1-m optical path above a standard cell-culture flask. Data-processing procedures for real-time monitoring of both biogenic and ambient atmospheric CO concentrations are described.

PACS: 42.62.Be; 82.80.Gk

Copyright information

© Springer-Verlag 2001