Applied Physics B

, Volume 95, Issue 2, pp 281–286

Infrared laser-spectroscopic analysis of 14NO and 15NO in human breath

Authors

  • K. Heinrich
    • Institut für LasermedizinUniversität Düsseldorf
  • T. Fritsch
    • Institut für LasermedizinUniversität Düsseldorf
  • P. Hering
    • Institut für LasermedizinUniversität Düsseldorf
    • Institut für LasermedizinUniversität Düsseldorf
Article

DOI: 10.1007/s00340-009-3423-1

Cite this article as:
Heinrich, K., Fritsch, T., Hering, P. et al. Appl. Phys. B (2009) 95: 281. doi:10.1007/s00340-009-3423-1
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Abstract

We report on monitoring of nitric oxide (NO) traces in human breath via infrared cavity leak-out spectroscopy. Using a CO sideband laser near 5 μm wavelength and an optical cavity with two high-reflectivity mirrors (R=99.98%), the minimum detectable absorption is 2×10−10 cm−1 Hz1/2. This allows for spectroscopic analysis of rare NO isotopologues with unprecedented sensitivity. Application to simultaneous online detection of 14NO and 15NO in breath samples collected in the nasal cavity is described for the first time. We achieved a noise-equivalent detection limit of 7 parts per trillion for nasal 15NO (integration time: 70 s).

PACS

33.57.+c42.62.Fi
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© Springer-Verlag 2009