Applied Physics B

, Volume 94, Issue 4, pp 667–672

Analysis of serum from type II diabetes mellitus and diabetic complication using surface-enhanced Raman spectra (SERS)

Authors

  • H. W. Han
    • School of Physical Science and Information TechnologyLiaocheng University
    • School of Physical Science and Information TechnologyLiaocheng University
  • R. X. Dong
    • School of Physical Science and Information TechnologyLiaocheng University
  • G. Ban
    • School of Physical Science and Information TechnologyLiaocheng University
  • K. Li
    • School of Physical Science and Information TechnologyLiaocheng University
Article

DOI: 10.1007/s00340-008-3299-5

Cite this article as:
Han, H.W., Yan, X.L., Dong, R.X. et al. Appl. Phys. B (2009) 94: 667. doi:10.1007/s00340-008-3299-5

Abstract

In this paper, we show surface-enhanced Raman spectra (SERS) of serums from type II diabetes mellitus and diabetic complication (coronary disease, glaucoma and cerebral infarction), and analyze the SERS through the multivariate statistical methods of principal component analysis (PCA). In particular, we find that there exist many adenines in these serums, which maybe come from DNA (RNA) damage. The relative intensity of the band at 725±2 cm−1 assigned to adenine is higher for patients than for the healthy volunteers; therefore, it can be used as an important ‘fingerprint’ in order to diagnose these diseases. It is also shown that serums from type II diabetes mellitus group, diabetic complication group and healthy volunteers group can be discriminated by PCA.

PACS

07.6087.0095.75Fs

Copyright information

© Springer-Verlag 2008