Applied Physics B

, Volume 85, Issue 2, pp 445–452

Quantum cascade laser-based integrated cavity output spectroscopy of exhaled nitric oxide


DOI: 10.1007/s00340-006-2365-0

Cite this article as:
McCurdy, M., Bakhirkin, Y. & Tittel, F. Appl. Phys. B (2006) 85: 445. doi:10.1007/s00340-006-2365-0


A nitric oxide (NO) sensor employing a thermoelectrically cooled, continuous-wave, distributed feedback quantum cascade laser operating at 5.47 μm (1828 cm-1) and off-axis integrated cavity output spectroscopy was used to measure NO concentrations in exhaled breath. A minimum measurable concentration (3σ) of 3.6 parts-per-billion by volume (ppbv) of NO with a data-acquisition time of 4 s was demonstrated. Five prepared gas mixtures and 15 exhaled breath samples were measured with both the NO sensor and for intercomparison with a chemiluminescence-based NO analyzer and were found to be in agreement within 0.6 ppbv. Exhaled NO flow-independent parameters, which may provide diagnostic and therapeutic information in respiratory diseases where single-breath measurements are equivocal, were estimated from end-tidal NO concentration measurements collected at various flow rates. The results of this work indicate that a laser-based exhaled NO sensor can be used to measure exhaled nitric oxide at a range of exhalation flow rates to determine flow-independent parameters in human clinical trials.

Copyright information

© Springer-Verlag 2006

Authors and Affiliations

  1. 1.Rice Quantum InstituteRice UniversityHoustonUSA
  2. 2.Medical Scientist Training ProgramBaylor College of MedicineHoustonUSA