, Volume 10, Issue 1, pp 44-48

Genomic organization and physical map of the human inhibitors of apoptosis: HIAP1 and HIAP2

Rent the article at a discount

Rent now

* Final gross prices may vary according to local VAT.

Get Access


We report the genomic organization, mapping, and tissue distribution of the human inhibitors of apoptosis, HIAP1 and HIAP2. HIAP1 is 8.7 kb in length and is contained within eight coding and two non-coding (5'UTR) exons. The 4.5-kb HIAP2 message is contained within eight coding region exons and a single 5'UTR exon. The HIAP1 and HIAP2 genes lie in tandem on Chromosome (Chr) 11 (q22-23) with the intergenic distance being approximately 7 kb. The tissue distributions of HIAP1 and HIAP2 appear similar although the relative expression of HIAP1 is generally higher. Expression is highest in the kidney, small intestine, liver, and lung and lowest in tissues of the central nervous system.

Received: 2 July 1998 / Accepted: 9 September 1998