Mammalian Genome

, Volume 10, Issue 1, pp 44–48

Genomic organization and physical map of the human inhibitors of apoptosis: HIAP1 and HIAP2

Authors

  • Sean S.  Young
    • Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, K1H 8M5, Canada
  • Peter  Liston
    • Apoptogen Inc., Ottawa, ON, K1H 8L1, Canada
  • Jian-Ying  Xuan
    • Solange Gauthier-Karsh Molecular Genetics Laboratory, Children's Hospital of Eastern Ontario Research Institute, Ottawa, ON, K1H 8L1, Canada
  • Christine  McRoberts
    • Apoptogen Inc., Ottawa, ON, K1H 8L1, Canada
  • Charles A.  Lefebvre
    • Apoptogen Inc., Ottawa, ON, K1H 8L1, Canada
  • Robert G.  Korneluk
    • Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, K1H 8M5, Canada

DOI: 10.1007/s003359900940

Cite this article as:
Young, S., Liston, P., Xuan, J. et al. (1999) 10: 44. doi:10.1007/s003359900940

Abstract.

We report the genomic organization, mapping, and tissue distribution of the human inhibitors of apoptosis, HIAP1 and HIAP2. HIAP1 is 8.7 kb in length and is contained within eight coding and two non-coding (5'UTR) exons. The 4.5-kb HIAP2 message is contained within eight coding region exons and a single 5'UTR exon. The HIAP1 and HIAP2 genes lie in tandem on Chromosome (Chr) 11 (q22-23) with the intergenic distance being approximately 7 kb. The tissue distributions of HIAP1 and HIAP2 appear similar although the relative expression of HIAP1 is generally higher. Expression is highest in the kidney, small intestine, liver, and lung and lowest in tissues of the central nervous system.

Copyright information

© Springer-Verlag New York Inc. 1999