Mammalian Genome

, Volume 9, Issue 9, pp 753–757

Conserved gene structure and genomic linkage for D-dopachrome tautomerase (DDT) and MIF

  • Noriko  Esumi
  • Marcia  Budarf
  • Lawrence  Ciccarelli
  • Beatrice  Sellinger
  • Christine A.  Kozak
  • Graeme  Wistow

DOI: 10.1007/s003359900858

Cite this article as:
Esumi, N., Budarf, M., Ciccarelli, L. et al. (1998) 9: 753. doi:10.1007/s003359900858

Abstract.

Macrophage migration inhibitory factor (MIF) and D-dopachrome tautomerase (DDT) are small proteins, which are related both by sequence and by in vitro enzyme activity. Here we show that the gene for DDT in human and mouse is identical in exon structure to MIF. Both genes have two introns that are located at equivalent positions, relative to a twofold repeat in protein structure. Although in similar positions, the introns are in different phases relative to the open reading frame. Other members of this superfamily exist in nematodes and a plant, and a related gene in C. elegans shares an intron position with MIF and DDT. In addition to similarities in structure, the genes for DDT and MIF are closely linked on human Chromosome (Chr) 22 and mouse Chr 10.

Copyright information

© Springer-Verlag New York Inc. 1998

Authors and Affiliations

  • Noriko  Esumi
    • 1
  • Marcia  Budarf
    • 2
  • Lawrence  Ciccarelli
    • 2
  • Beatrice  Sellinger
    • 2
  • Christine A.  Kozak
    • 4
  • Graeme  Wistow
    • 1
  1. 1.Section on Molecular Structure and Function, National Eye Institute, Building 6 Room 331, National Institutes of Health, Bethesda, Maryland 20892-2740, USAUS
  2. 2.Dept. of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USAUS
  3. 3.The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, 19104-4399, USAUS
  4. 4.Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases National Institutes of Health, Bethesda, Maryland 20892 USAUS