Original Contribution

Mammalian Genome

, Volume 8, Issue 11, pp 801-804

First online:

Pas1 is a common lung cancer susceptibility locus in three mouse strains

  • Giacomo ManentiAffiliated withDivision of Experimental Oncology A, Istituto Nazionale Tumori
  • , Manuela GariboldiAffiliated withDivision of Experimental Oncology A, Istituto Nazionale Tumori
  • , Antonio FiorinoAffiliated withDivision of Experimental Oncology A, Istituto Nazionale Tumori
  • , Antonio I. ZeddaAffiliated withDivision of Experimental Oncology A, Istituto Nazionale Tumori
  • , Marco A. PierottiAffiliated withDivision of Experimental Oncology A, Istituto Nazionale Tumori
  • , Tommaso A. DraganiAffiliated withDivision of Experimental Oncology A, Istituto Nazionale Tumori

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Abstract

Inherited predisposition to lung cancer is a phenotypic trait shared by different mouse inbred strains that show either a high or an intermediate predisposition. Other strains are instead genetically resistant. The Pasl locus is the major determinant of lung cancer predisposition in the A/J strain (Gariboldi et al. 1993). To define the determinants of susceptibility to lung tumorigenesis in the highly susceptible SWR/J and in the intermediately susceptible BALB/c mice, we analyzed (BALB/c x SWR/J)F2 and (BALB/c x C3H/He)F2 crosses by genetic linkage experiments. The present results provide unequivocal evidence that the same Pas1/+ allele that leads to lung cancer predisposition is shared by A/J, SWR/J, and BALB/c strains. The intermediate susceptibility of the BALB/c strain would result by interaction of Pas1 locus with lung cancer resistance loci.