Mammalian Genome

, Volume 7, Issue 5, pp 359–362

A class of highly polymorphic tetranucleotide repeats for canine genetic mapping

  • L. V. Francisco
  • A. A. Langsten
  • C. S. Mellersh
  • C. L. Neal
  • E. A. Ostrander
Original Contribution

DOI: 10.1007/s003359900104

Cite this article as:
Francisco, L.V., Langsten, A.A., Mellersh, C.S. et al. Mammalian Genome (1996) 7: 359. doi:10.1007/s003359900104

Abstract

We have identified and characterized a new class of polymorphic markers for the canine genome from a simple tetranucleotide repeat sequence, (GAAA)n. Genetic markers derived from this repeat are highly polymorphic compared with other canine microsatellites, yet are stable enough to be useful for following Mendelian inheritance in multigeneration pedigrees. We show further that (GAAA)n repeats are distributed throughout the canine genome and occur with sufficient frequency to be useful in the development of a framework map of the canine genome.

Copyright information

© Springer-Verlag 1996

Authors and Affiliations

  • L. V. Francisco
    • 1
  • A. A. Langsten
    • 1
  • C. S. Mellersh
    • 1
  • C. L. Neal
    • 1
  • E. A. Ostrander
    • 1
    • 2
  1. 1.Program in Transplantation Biology, Clinical Research Division, M318Fred Hutchinson Cancer Research CenterSeattleUSA
  2. 2.Program in Molecular MedicineFred Hutchinson Cancer Research CenterSeattleUSA