Omi, a recessive mutation on chromosome 10, is a novel allele of Ostm1
- Erika A. BosmanAffiliated withWellcome Trust Sanger Institute
- , Jeanne EstabelAffiliated withWellcome Trust Sanger Institute
- , Ozama IsmailAffiliated withWellcome Trust Sanger Institute
- , Christine PodriniAffiliated withWellcome Trust Sanger Institute
- , Jacqueline K. WhiteAffiliated withWellcome Trust Sanger Institute
- , Karen P. SteelAffiliated withWellcome Trust Sanger Institute Email author
Large-scale N-ethyl-N-nitrosourea (ENU) mutagenesis has provided many rodent models for human disease. Here we describe the initial characterization and mapping of a recessive mutation that leads to degeneration of the incisors, failure of molars to erupt, a grey coat colour, and mild osteopetrosis. We mapped the omi mutation to chromosome 10 between D10Mit214 and D10Mit194. The Ostm1 gene is a likely candidate gene in this region and the grey-lethal allele, Ostm1 gl , and omi mutations fail to complement each other. We show that om/om mice have reduced levels of Ostm1 protein. To date we have not been able to identify the causative mutation. We propose that omi is a novel hypomorphic mutation affecting Ostm1 expression, potentially in a regulatory element.
- Omi, a recessive mutation on chromosome 10, is a novel allele of Ostm1
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Volume 24, Issue 1-2 , pp 44-53
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