Mammalian Genome

, Volume 24, Issue 1, pp 44-53

First online:

Open Access This content is freely available online to anyone, anywhere at any time.

Omi, a recessive mutation on chromosome 10, is a novel allele of Ostm1

  • Erika A. BosmanAffiliated withWellcome Trust Sanger Institute
  • , Jeanne EstabelAffiliated withWellcome Trust Sanger Institute
  • , Ozama IsmailAffiliated withWellcome Trust Sanger Institute
  • , Christine PodriniAffiliated withWellcome Trust Sanger Institute
  • , Jacqueline K. WhiteAffiliated withWellcome Trust Sanger Institute
  • , Karen P. SteelAffiliated withWellcome Trust Sanger Institute Email author 


Large-scale N-ethyl-N-nitrosourea (ENU) mutagenesis has provided many rodent models for human disease. Here we describe the initial characterization and mapping of a recessive mutation that leads to degeneration of the incisors, failure of molars to erupt, a grey coat colour, and mild osteopetrosis. We mapped the omi mutation to chromosome 10 between D10Mit214 and D10Mit194. The Ostm1 gene is a likely candidate gene in this region and the grey-lethal allele, Ostm1 gl , and omi mutations fail to complement each other. We show that om/om mice have reduced levels of Ostm1 protein. To date we have not been able to identify the causative mutation. We propose that omi is a novel hypomorphic mutation affecting Ostm1 expression, potentially in a regulatory element.