Mammalian Genome

, Volume 20, Issue 9, pp 544–556

Chromatin mechanisms in genomic imprinting


DOI: 10.1007/s00335-009-9223-4

Cite this article as:
Kacem, S. & Feil, R. Mamm Genome (2009) 20: 544. doi:10.1007/s00335-009-9223-4


Mammalian imprinted genes are clustered in chromosomal domains. Their mono-allelic, parent-of-origin-specific expression is regulated by imprinting control regions (ICRs), which are essential sequence elements marked by DNA methylation on one of the two parental alleles. These methylation “imprints” are established during gametogenesis and, after fertilization, are somatically maintained throughout development. Nonhistone proteins and histone modifications contribute to this epigenetic process. The way ICRs mediate imprinted gene expression differs between domains. At some domains, for instance, ICRs produce long noncoding RNAs that mediate chromatin silencing. Lysine methylation on histone H3 is involved in this developmental process and is particularly important for imprinting in the placenta and brain. Together, the newly discovered chromatin mechanisms provide further clues for addressing imprinting-related pathologies in humans.

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© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  1. 1.CNRS and University of Montpellier I and IIMontpellierFrance
  2. 2.Institute of Molecular Genetics (IGMM)CNRS-UMR 5535Montpellier Cedex 5France
  3. 3.Department of Cytogenetics, Molecular Genetics, and Biology of ReproductionFarhat Hached HospitalSousseTunisia