Mammalian Genome

, Volume 19, Issue 6, pp 429–438

Combined line-cross and half-sib QTL analysis in Duroc–Pietrain population

  • Guisheng Liu
  • Jong Joo Kim
  • Elisebeth Jonas
  • Klaus Wimmers
  • Siriluck Ponsuksili
  • Eduard Murani
  • Chirawath Phatsara
  • Ernst Tholen
  • Heinz Juengst
  • Dawit Tesfaye
  • Ji Lan Chen
  • Karl Schellander
Article

DOI: 10.1007/s00335-008-9132-y

Cite this article as:
Liu, G., Kim, J.J., Jonas, E. et al. Mamm Genome (2008) 19: 429. doi:10.1007/s00335-008-9132-y

Abstract

A Duroc–Pietrain resource population was built to detect quantitative trait loci (QTL) that affect growth, carcass composition, and pork quality. The data were analyzed by applying three least-squares Mendelian models: a line-cross (LC) model, a half-sib (HS) model, and a combined LC and HS model (CB), which enabled the detection of QTL that had fixed, equal, and different allele frequencies for alternate breed alleles, respectively. Permutation tests were performed to determine 5% chromosome-wide and 5% genome-wide threshold values. A total of 40 (137) QTL were detected at the 5% genome-wide (chromosome-wide) level for the 35 traits analyzed. Of the 137 QTL detected, 62 were classified as the LC type (LC-QTL), 47 as the HS type (HS-QTL), and 28 as the CB type (CB-QTL). The results indicate that implementation of a series of model-based framework is not only beneficial to detect QTL, but also provides us with a new and more robust interpretation from which further methodology could be developed.

Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Guisheng Liu
    • 1
    • 2
  • Jong Joo Kim
    • 3
  • Elisebeth Jonas
    • 1
  • Klaus Wimmers
    • 4
  • Siriluck Ponsuksili
    • 4
  • Eduard Murani
    • 4
  • Chirawath Phatsara
    • 1
  • Ernst Tholen
    • 1
  • Heinz Juengst
    • 1
  • Dawit Tesfaye
    • 1
  • Ji Lan Chen
    • 5
  • Karl Schellander
    • 1
  1. 1.Animal Breeding and Husbandry Group, Institute of Animal ScienceUniversity of BonnBonnGermany
  2. 2.Hubei Key Lab of Animal Embryo Engineering and Molecular BreedingInstitute of Animal and Veterinary Science, Hubei Academy of Agricultural ScienceHubei ProvinceChina
  3. 3.School of BiotechnologyYeungnam UniversityGyeongsanKorea
  4. 4.Research Institute for the Biology of Farm Animals (FBN)DummerstorfGermany
  5. 5.Beijing Institute of Animal and Veterinary Science, China Academy of Agricultural ScienceBeijingChina