The power of comparative and developmental studies for mouse models of Down syndrome
- Clara S. MooreAffiliated withDepartment of Biology, Franklin and Marshall College
- , Randall J. RoperAffiliated withDepartment of Biology, Indiana University-Purdue University Indianapolis Email author
Since the genetic basis for Down syndrome (DS) was described, understanding the causative relationship between genes at dosage imbalance and phenotypes associated with DS has been a principal goal of researchers studying trisomy 21 (Ts21). Though inferences to the gene-phenotype relationship in humans have been made, evidence linking a specific gene or region to a particular congenital phenotype has been limited. To further understand the genetic basis for DS phenotypes, mouse models with three copies of human chromosome 21 (Hsa21) orthologs have been developed. Mouse models offer access to every tissue at each stage of development, opportunity to manipulate genetic content, and ability to precisely quantify phenotypes. Numerous approaches to recreate trisomic composition and analyze phenotypes similar to DS have resulted in diverse trisomic mouse models. A murine intraspecies comparative analysis of different genetic models of Ts21 and specific DS phenotypes reveals the complexity of trisomy and important considerations to understand the etiology of and strategies for amelioration or prevention of trisomic phenotypes. By analyzing individual phenotypes in different mouse models throughout development, such as neurologic, craniofacial, and cardiovascular abnormalities, greater insight into the gene-phenotype relationship has been demonstrated. In this review we discuss how phenotype-based comparisons between DS mouse models have been useful in analyzing the relationship of trisomy and DS phenotypes.
- The power of comparative and developmental studies for mouse models of Down syndrome
- Open Access
- Available under Open Access This content is freely available online to anyone, anywhere at any time.
Volume 18, Issue 6-7 , pp 431-443
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- Author Affiliations
- 1. Department of Biology, Franklin and Marshall College, Lancaster, Pennsylvania, 17604, USA
- 2. Department of Biology, Indiana University-Purdue University Indianapolis, 723 W. Michigan Street, SL 306, Indianapolis, Indiana, 46202, USA