Mammalian Genome

, Volume 16, Issue 8, pp 578–586

Genome screen for bone mineral density phenotypes in Fisher 344 and Lewis rat strains

Authors

    • Department of Medical and Molecular GeneticsIndiana University School of Medicine
  • Imranul Alam
    • Department of Biomedical EngineeringIndiana University-Purdue University Indianapolis
  • Qiwei Sun
    • Department of Biomedical EngineeringIndiana University-Purdue University Indianapolis
  • Lixiang Liu
    • Department of Medical and Molecular GeneticsIndiana University School of Medicine
  • Tonya Fishburn
    • Department of Medicine, Division of EndocrinologyIndiana University School of Medicine
  • Lucinda G. Carr
    • Department of Medicine, Division of EndocrinologyIndiana University School of Medicine
  • Michael J. Econs
    • Department of Medical and Molecular GeneticsIndiana University School of Medicine
    • Department of Medicine, Division of EndocrinologyIndiana University School of Medicine
  • Tatiana Foroud
    • Department of Medical and Molecular GeneticsIndiana University School of Medicine
  • Charles H. Turner
    • Department of Biomedical EngineeringIndiana University-Purdue University Indianapolis
    • Department of Orthopaedic SurgeryIndiana University School of Medicine
Article

DOI: 10.1007/s00335-004-2459-0

Cite this article as:
Koller, D.L., Alam, I., Sun, Q. et al. Mamm Genome (2005) 16: 578. doi:10.1007/s00335-004-2459-0

Abstract

In humans, peak bone mineral density (BMD) is the primary determinant of osteoporotic fracture risk among older individuals, with high peak BMD levels providing protection against osteoporosis in the almost certain event of bone loss later in life. A genome screen to identify quantitative trait loci (QTLs) contributing to areal BMD (aBMD) and volumetric BMD (vBMD) measurements at the lumbar spine and femoral neck was completed in 595 female F2 rats produced from reciprocal crosses of inbred Fischer 344 and Lewis rats. Significant evidence of linkage was detected to rat Chromosomes 1, 2, 8, and 10, with LOD scores above 8.0. The region on rat Chromosome 8 is syntenic to human Chromosome 15, where linkage to spine and femur BMD has been previously reported and confirmed in a sample of premenopausal women.

Copyright information

© Springer Science+Business Media Inc. 2005