Mammalian Genome

, Volume 15, Issue 1, pp 53–61

Comparative mapping of rat Iddm4 to segments on HSA7 and MMU6

  • Lars Hornum
  • Cheryl DeScipio
  • Helle Markholst
  • Scott A. Troutman
  • Stephen Novak
  • Jean Leif
  • Dale Greiner
  • John P. Mordes
  • Elizabeth P. Blankenhorn
Article

DOI: 10.1007/s00335-003-3023-z

Cite this article as:
Hornum, L., DeScipio, C., Markholst, H. et al. Mamm Genome (2004) 15: 53. doi:10.1007/s00335-003-3023-z

Abstract

Iddm4 is one of several susceptibility genes that have been identified in the BB rat model of type 1 diabetes. The BB rat allele of this gene confers dominant predisposition to diabetes induction by immune perturbation in both the diabetes-prone and the diabetes-resistant substrains, whereas the Wistar Furth (WF) allele confers resistance. We have positioned the gene in a 2.8-cM region on rat Chromosome (Chr) 4, proximal to Lyp/Ian4l1. We have produced a radiation hybrid map of the Iddm4-region that includes a number of rat genes with their mouse and human orthologs. We present a comparative map of the rat Iddm4 region in rat, human, and mouse, assigning the gene to a 6.3-Mb segment between PTN and ZYX at 7q32 in the human genome, and to a 5.7-Mb segment between Ptn and Zyx in the mouse genome.

Copyright information

© Springer-Verlag New York Inc. 2004

Authors and Affiliations

  • Lars Hornum
    • 1
  • Cheryl DeScipio
    • 2
  • Helle Markholst
    • 1
  • Scott A. Troutman
    • 2
  • Stephen Novak
    • 2
  • Jean Leif
    • 3
  • Dale Greiner
    • 3
  • John P. Mordes
    • 3
  • Elizabeth P. Blankenhorn
    • 2
  1. 1.Hagedorn Research Institute, Niels Steensens Vej 6, DK-2820 GentofteDenmark
  2. 2.Department of Microbiology and ImmunologyDrexel University College of Medicine, 2900 Queen Lane, Philadelphia, Pennsylvania 19129USA
  3. 3.Diabetes DivisionUniversity of Massachusetts Medical School, 373 Plantation Street, #218, Worcester, MassachusettsUSA