Mammalian Genome

, Volume 14, Issue 9, pp 629–639

Comparative map between chicken Chromosome 15 and human chromosomal region 12q24 and 22q11-q12

  • Danyel G. J. Jennen
  • Richard P. M. A. Crooijmans
  • Bram Kamps
  • Rukiye Açar
  • Jan J. van der Poel
  • Martien A. M. Groenen
Article

DOI: 10.1007/s00335-003-3007-z

Cite this article as:
Jennen, D.G., Crooijmans, R.P., Kamps, B. et al. Mamm Genome (2003) 14: 629. doi:10.1007/s00335-003-3007-z

Abstract

The physical and comparative map of GGA15 was improved by the construction of 9 BAC contigs around loci previously mapped on GGA15 by linkage analysis. In total, 240 BAC clones were isolated, covering 30–35% of GGA15, and 120 STS were developed (104 STS derived from BAC end sequences and 18 STS derived within genes). Seventeen chicken orthologues of human genes located on human Chr 22q11-q12 were directly mapped within BAC contigs of GGA15. Furthermore, the partial sequences of the chicken BAC clones were compared with sequences present in the EMBL/GenBank databases and revealed matches to 26 genes, ESTs, and genomic clones located on HSA22q11-q12 and HSA12q24. These results provide a better alignment of GGA15 with the corresponding regions in human and mouse, and improve our knowledge of the evolution and dynamics of the vertebrate genome.

Copyright information

© Springer-Verlag New York Inc. 2003

Authors and Affiliations

  • Danyel G. J. Jennen
    • 1
  • Richard P. M. A. Crooijmans
    • 1
  • Bram Kamps
    • 1
  • Rukiye Açar
    • 1
  • Jan J. van der Poel
    • 1
  • Martien A. M. Groenen
    • 1
  1. 1.Wageningen Institute of Animal Sciences, Animal Breeding and Genetics GroupWageningen University, Marijkeweg 40, 6709 PG WageningenThe Netherlands