Mammalian Genome

, Volume 13, Issue 10, pp 588–594

A mapping and evolutionary study of porcine sex chromosome gene

Authors

  • Claire R. Quilter
    • Human Molecular Genetics Group, Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK
  • Sarah C. Blott
    • Human Molecular Genetics Group, Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK
  • Alan J. Mileham
    • Sygen International, 2929 7th Street, Suite 130, Berkeley, California 94710, USA
  • Nabeel A. Affara
    • Human Molecular Genetics Group, Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK
  • Carole A. Sargent
    • Human Molecular Genetics Group, Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK
  • Darren K. Griffin
    • Department of Biological Sciences, Brunel University, Uxbridge, Middlesex, UB8 3PH, UK

DOI: 10.1007/s00335-002-3026-1

Cite this article as:
Quilter, C., Blott, S., Mileham, A. et al. Mamm Genome (2002) 13: 588. doi:10.1007/s00335-002-3026-1

A combination of FISH and RH mapping was used to study the evolution of sex chromosome genes in the pig. In total, 19 genes were identified, including 3 PAR genes (STS, KAL, PRK). The gene order of the porcine X Chromosome (Chr) closely resembled the human X Chr (PRK/STS/KAL–AMELX–EIF2s3X/ZFX–USP9X–DBX–SMCX), suggesting that the porcine X has undergone very little rearrangement during evolution. For the porcine Y Chr, two linkage groups of 10 NRY genes were found, and the following order was established: Ypter–(AMELY–EIF2S3Y/ZFY–USP9Y–DBY/UTY)–(TSPY–SMCY–UBE1Y–SRY)–CEN. This gene order showed greater conservation with the murine Y than with the human Y Chr. In addition, all porcine Y Chr genes mapped to Yp, which is similar to the mouse and included EIF2s3Y and UBE1Y, which are not present in humans. Interestingly, complete conservation of X/Y homologous gene order was found between the pig X and Y Chrs, indicating that the porcine Y Chr has not undergone extensive reorganisation with respect to the X. This suggests that the order of the X/Y homologous genes of the porcine X and Y Chrs may closely resemble the ancestral gene order of the eutherian sex chromosomes.

Copyright information

© Springer-Verlag New York Inc. 2002