Mammalian Genome

, Volume 14, Issue 7, pp 448–453

A major locus conferring susceptibility to infection by Streptococcus pneumoniae in mice

  • Paul Denny
  • Elaine Hopes
  • Neill Gingles
  • Karl W. Broman
  • William McPheat
  • John Morten
  • Janet Alexander
  • Peter W. Andrew
  • Steve D. M. Brown
Article

DOI: 10.1007/s00335-002-2261-9

Cite this article as:
Denny, P., Hopes, E., Gingles, N. et al. Mamm Genome (2003) 14: 448. doi:10.1007/s00335-002-2261-9

Abstract

We have studied the genetics of susceptibility to infection by Streptococcuspneumoniae in mice. Linkage analysis of the F2 generation from a cross between resistant BALB/cO1aHsd and susceptible CBA/CaO1aHsd strains allowed us to map a major locus controlling the development of bacteremia and survival after intranasal infection.

Copyright information

© Springer-Verlag New York Inc. 2003

Authors and Affiliations

  • Paul Denny
    • 1
  • Elaine Hopes
    • 1
  • Neill Gingles
    • 2
  • Karl W. Broman
    • 3
  • William McPheat
    • 5
  • John Morten
    • 4
  • Janet Alexander
    • 2
  • Peter W. Andrew
    • 2
  • Steve D. M. Brown
    • 1
  1. 1.MRC UK Mouse Genome Centre & Mammalian Genetics Unit, Harwell, Oxon, OX11 0RDUK
  2. 2.Department of Microbiology and ImmunologyUniversity of Leicester, LeicesterUK
  3. 3.Department of BiostatisticsJohns Hopkins University, Baltimore, MarylandUSA
  4. 4.Research and Development GeneticsAstraZeneca, Alderley Park, Macclesfield, CheshireUK
  5. 5.Cell Biology and BiochemistryAstraZeneca R&D Mölndal, Pepparedsleden 1, 431 83 MölndalSweden