A major locus conferring susceptibility to infection by Streptococcus pneumoniae in mice
- Cite this article as:
- Denny, P., Hopes, E., Gingles, N. et al. Mamm Genome (2003) 14: 448. doi:10.1007/s00335-002-2261-9
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We have studied the genetics of susceptibility to infection by Streptococcuspneumoniae in mice. Linkage analysis of the F2 generation from a cross between resistant BALB/cO1aHsd and susceptible CBA/CaO1aHsd strains allowed us to map a major locus controlling the development of bacteremia and survival after intranasal infection.