Mammalian Genome

, Volume 14, Issue 9, pp 650–656

Detection of QTL affecting fatty acid composition in the pig

  • Alex Clop
  • Cristina Ovilo
  • Miguel Perez-Enciso
  • Albert Cercos
  • Anna Tomas
  • Ana Fernandez
  • Agustina Coll
  • Josep M. Folch
  • Carmen Barragan
  • Isabel Diaz
  • Maria A. Oliver
  • Luis Varona
  • Luis Silio
  • Armand Sanchez
  • Jose L. Noguera
Article

DOI: 10.1007/s00335-002-2210-7

Cite this article as:
Clop, A., Ovilo, C., Perez-Enciso, M. et al. Mamm Genome (2003) 14: 650. doi:10.1007/s00335-002-2210-7
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Abstract

We present a QTL genome scan for fatty acid composition in pigs. An F2 cross between Iberian × Landrace pigs and a regression approach fitting the carcass weight as a covariate for QTL identification was used. Chromosomes (Chrs) 4, 6, 8, 10, and 12 showed highly significant effects. The Chr 4 QTL influenced the linoleic content and both the fatty acid double-bond index and peroxidability index. In Chr 6 we found significant associations with the double-bond index and the unsaturated index of fatty acids. Chr 8 showed clear effects on the percentages of palmitic and palmitoleic fatty acids as well as the average chain length of fatty acids. In Chr 10 we detected a significant QTL for the percentage of myristic fatty acid, with an F value that was slightly above the genomewide threshold. The percentage of linolenic fatty acid was affected by a region on Chr 12. A nearly significant QTL for the content of gadoleic fatty acid was also detected in Chr 12. We also analyzed the genomic QTL distribution by a regression model that fits the backfat thickness as a covariate. Some of the QTL that were detected in our analysis could not be detected when the data were corrected by backfat thickness. This work shows how critical the selection of a covariate can be in the interpretation of results. This is the first report of a genome scan detection of QTL directly affecting fatty acid composition in pigs.

Copyright information

© Springer-Verlag New York Inc. 2003

Authors and Affiliations

  • Alex Clop
    • 1
  • Cristina Ovilo
    • 2
  • Miguel Perez-Enciso
    • 3
  • Albert Cercos
    • 1
  • Anna Tomas
    • 1
  • Ana Fernandez
    • 2
  • Agustina Coll
    • 1
  • Josep M. Folch
    • 1
  • Carmen Barragan
    • 2
  • Isabel Diaz
    • 4
  • Maria A. Oliver
    • 4
  • Luis Varona
    • 3
  • Luis Silio
    • 2
  • Armand Sanchez
    • 1
  • Jose L. Noguera
    • 3
  1. 1.Department de Ciència Animal i dels Aliments, Facultat de VeterinàriaUniversitat Autònoma de Barcelona, Bellaterra, 08193Spain
  2. 2.Area de Genética y Mejora AnimalSGIT-INIA, Ctra. De la Coruña km. 7, Madrid, 28040Spain
  3. 3.Area de Producció Animal, Centre UdL-IRTA, C/ Alcalde Rovira Roure 177, Lleida, 25198Spain
  4. 4.IRTA-CTC, Monells, 17121, GironaSpain