Mammalian Genome

, Volume 12, Issue 8, pp 590–594

Source and component genes of a 6–200 Mb gene cluster in the house mouse

  • Dieter  Weichenhan
  • Bärbel  Kunze
  • Heinz  Winking
  • Michel  van Geel
  • Kazutoyo  Osoegawa
  • Pieter J.  de Jong
  • Walther  Traut
Article

DOI: 10.1007/s00335-001-3015-9

Cite this article as:
Weichenhan, D., Kunze, B., Winking, H. et al. Mammalian Genome (2001) 12: 590. doi:10.1007/s00335-001-3015-9

Abstract

We identified and analyzed the genes Sp100, Csprs, and Ifi75 in two members of the genus Mus, M. musculus and M. caroli. Sp100 is a nuclear dot gene; Csprs and Ifi75 are novel genes encoding a putative G-protein coupled receptor (GPCR) and a putative transcriptional coactivator, respectively. A fourth gene, Sp100-rs, occurs in M. musculus, but not in M. caroli. Sp100-rs is a chimeric gene which arose by fusion of Sp100 and Csprs copies. Sp100-rs and Ifi75 are components of a repeat cluster that extends over 6–200 Mb of the M. musculus genome. The Sp100-rs fusion gene arose only 1–2 million years ago and has become fixed and amplified in M. musculus. Although the gene is transcribed, it appears to have no function. The repeat cluster may have become fixed in the species as a `hitchhiker' in a `selective sweep'.

Copyright information

© Springer-Verlag New York Inc. 2001

Authors and Affiliations

  • Dieter  Weichenhan
    • 1
  • Bärbel  Kunze
    • 1
  • Heinz  Winking
    • 1
  • Michel  van Geel
    • 2
  • Kazutoyo  Osoegawa
    • 3
  • Pieter J.  de Jong
    • 4
  • Walther  Traut
    • 1
  1. 1.Institut für Biologie, Medizinische Universität zu Lübeck, Ratzeburger Allee 160, D-23538 Lübeck, GermanyDE
  2. 2.Department of Dermatology, University Hospital Nijmegen, Building M321, PO box 9101, 6500 HB, Rene Descartesdreef 1, 6525 GL, Nijmegen, The NetherlandsNL
  3. 3.Children's Hospital, Oakland Research Institute, BACPAC Resources, 747 52nd St., Oakland, California 94609, USAUS
  4. 4.Parke-Davis-Lab for Molecular Genetics, 1501 Bay Harbor Parkway, Alameda, California 94502, USAUS

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