Mammalian Genome

, Volume 13, Issue 1, pp 41–44

Multiple blood pressure QTL on rat Chromosome 2 defined by congenic Dahl rats

  • Michael R. Garrett
  • John P. Rapp
Article

DOI: 10.1007/s00335-001-2114-y

Cite this article as:
Garrett, M.R. & Rapp, J.P. Mammalian Genome (2002) 13: 41. doi:10.1007/s00335-001-2114-y

Abstract

Linkage analysis previously demonstrated a blood pressure quantitative trait locus (QTL) on rat Chromosome 2 (Chr 2) in crosses utilizing Dahl salt-sensitive (S) rats. The present work dissects this QTL by using congenic strains in which segments of Chr 2 from Wistar Kyoto rats (WKY) are placed on the S genetic background. Two distinct QTLs were found where one QTL was anticipated. These each accounted for a blood pressure of 15–20 mm Hg in rats fed 2% NaCl diet for 24 days. One QTL was in the <9-cM interval between D2Rat35 and D2Wox18 (Fgg), and the other was in the <7-cM interval between D2Wox18 (Fgg) and D2Mgh10. A third tentative QTL was suggested, but not clearly established, in the <3-cM interval between D2Mgh10 and D2Rat259.

Copyright information

© Springer-Verlag New York Inc. 2002

Authors and Affiliations

  • Michael R. Garrett
    • 1
  • John P. Rapp
    • 1
  1. 1.Department of Physiology and Molecular Medicine, Medical College of Ohio, 3035 Arlington Avenue, Toledo, Ohio 43614-5805, USAUSA