European Radiology

, Volume 8, Issue 2, pp 194–200

Detection of breast cancer with conventional mammography and contrast-enhanced MR imaging

Authors

  • G. M. Kacl
    • Department of Diagnostic Radiology, Zurich University Hospital, Rämistrasse 100, CH-8091 Zurich, Switzerland
  • P.-F. Liu
    • Department of Diagnostic Radiology, Zurich University Hospital, Rämistrasse 100, CH-8091 Zurich, Switzerland
  • J. F. Debatin
    • Department of Diagnostic Radiology, Zurich University Hospital, Rämistrasse 100, CH-8091 Zurich, Switzerland
  • E. Garzoli
    • Department of Diagnostic Radiology, Zurich University Hospital, Rämistrasse 100, CH-8091 Zurich, Switzerland
  • R. F. Caduff
    • Department of Pathology, Zurich University Hospital, Rämistrasse 100, CH-8091 Zurich, Switzerland
  • G. P. Krestin
    • Department of Diagnostic Radiology, Zurich University Hospital, Rämistrasse 100, CH-8091 Zurich, Switzerland
Original article, Breast radiology

DOI: 10.1007/s003300050362

Cite this article as:
Kacl, G., Liu, P., Debatin, J. et al. Eur Radiol (1998) 8: 194. doi:10.1007/s003300050362

Abstract

The aim of this study was to compare the diagnostic performance of conventional mammography and dynamic contrast-enhanced fast 3D gradient-echo (GRE) MRI regarding the detection and characterization of breast lesions relative to histopathologic analysis and to assess the results of a combined evaluation of both methods. fifty consecutive patients with 63 histopathologically verified breast lesions underwent dynamic contrast-enhanced GRE MRI in addition to routine conventional mammography. All lesions were classified by both methods on a five-point scale as benign or malignant, and the results were correlated to histopathology. Conventional mammography and dynamic MRI yielded a sensitivity and specificity of 82 and 64 %, and 92 and 76 %, respectively. The difference between the results was statistically not significant (p > 0.05) with areas under the receiver-operating-characteristics curves of 0.807 for mammography and 0.906 for MR imaging. Combination of the results of both methods slightly increased the sensitivity for detection of breast cancer to 95 % but decreased specificity to 52 %. In this selected patient subset, including only patients referred for excisional biopsy, contrast-enhanced dynamic MRI proved more sensitive and specific than conventional mammography regarding the detection of malignancy. While a combination of both methods yields a slightly improved sensitivity, specificity is vastly reduced.

Key words: Breast MRIMammographyBreast neoplasmContrast-enhanced MRI

Copyright information

© Springer-Verlag Berlin Heidelberg 1998