European Radiology

, Volume 11, Issue 6, pp 1039–1046

Diagnostic utility of an echo-contrast agent in patients with synovitis using power Doppler ultrasound: a preliminary study with comparison to contrast-enhanced MRI

  • Nicola Magarelli
  • Giuseppe Guglielmi
  • Luigi Di Matteo
  • Armando Tartaro
  • Peter A. Mattei
  • Lorenzo Bonomo
MUSCULOSKELETAL

DOI: 10.1007/s003300000650

Cite this article as:
Magarelli, N., Guglielmi, G., Di Matteo, L. et al. Eur Radiol (2001) 11: 1039. doi:10.1007/s003300000650

Abstract

The purpose of this study was to first evaluate Levovist (Schering, Berlin, Germany), an echo-contrast agent, during power Doppler sonography (PDS) in patients with synovitis using asymptomatic joints as controls. Then we evaluated the accuracy of this technique against contrast-enhanced MRI. Forty patients (19 men and 21 women; mean age 40 years) were enrolled on the basis of clinical signs, laboratory tests, and radiographic findings positive for articular inflammatory disease. They were examined with conventional ultrasonography (US) and PDS techniques before and after intravenous contrast medium injection. Fourteen patients then underwent MRI with and without contrast medium 8–14 days after PDS studies. Three expert readers independently evaluated each examination. After contrast medium, synovium in inflammatory arthritis enhanced on PDS compared with normal joints in the same patient. Power Doppler sonography after contrast medium and MRI were concordant in all cases. Power Doppler sonography with contrast medium showed a qualitative increase in signal from synovial vessels, the first sign of synovial changes in inflammatory diseases.

Key words Ultrasound Power Doppler studies Contrast medium and power Doppler Synovitis and power Doppler Synovitis and contrast enhancement MR Fat suppression 

Copyright information

© Springer-Verlag 2001

Authors and Affiliations

  • Nicola Magarelli
    • 1
  • Giuseppe Guglielmi
    • 2
  • Luigi Di Matteo
    • 3
  • Armando Tartaro
    • 1
  • Peter A. Mattei
    • 4
  • Lorenzo Bonomo
    • 1
  1. 1.Istituto di Radiologia, Università“G. D'Annunzio” di Chieti, Ospedale “SS Annunziata”, via dei Vestini, 66100 Chieti, Italy Tel.: + 39-08 71-35 82 37 Fax: + 39-08 71-34 49 55IT
  2. 2.Istituto di Radiologia, “Casa Sollievo della Sofferenza” IRCCS, 71013 San Giovanni Rotondo (FG), ItalyIT
  3. 3.Istituto di Reumatologia, Ospedale di Pescara, 65100 Pescara, ItalyIT
  4. 4.Facoltà di Medicina, Università“G. D'Annunzio”, via dei Vestini, 66100 Chieti, ItalyIT

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