Clinical application of bilateral high temporal and spatial resolution dynamic contrast-enhanced magnetic resonance imaging of the breast at 7 T
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The objective of our study was to evaluate the clinical application of bilateral high spatial and temporal resolution dynamic contrast-enhanced magnetic resonance imaging (HR DCE-MRI) of the breast at 7 T.
Following institutional review board approval 23 patients with a breast lesion (BIRADS 0, 4–5) were included in our prospective study. All patients underwent bilateral HR DCE-MRI of the breast at 7 T (spatial resolution of 0.7 mm3 voxel size, temporal resolution of 14 s). Two experienced readers (r1, r2) and one less experienced reader (r3) independently assessed lesions according to BI-RADS®. Image quality, lesion conspicuity and artefacts were graded from 1 to 5. Sensitivity, specificity and diagnostic accuracy were assessed using histopathology as the standard of reference.
HR DCE-MRI at 7 T revealed 29 lesions in 23 patients (sensitivity 100 % (19/19); specificity of 90 % (9/10)) resulting in a diagnostic accuracy of 96.6 % (28/29) with an AUC of 0.95. Overall image quality was excellent in the majority of cases (27/29) and examinations were not hampered by artefacts. There was excellent inter-reader agreement for diagnosis and image quality parameters (κ = 0.89–1).
Bilateral HR DCE-MRI of the breast at 7 T is feasible with excellent image quality in clinical practice and allows accurate breast cancer diagnosis.
• Dynamic contrast-enhanced 7-T MRI is being developed in several centres.
• Bilateral high resolution DCE-MRI of the breast at 7 T is clinically applicable.
• 7-T HR DCE-MRI of the breast provides excellent image quality.
• 7-T HR DCE-MRI should detect breast cancer with high diagnostic accuracy.
- Clinical application of bilateral high temporal and spatial resolution dynamic contrast-enhanced magnetic resonance imaging of the breast at 7 T
Volume 24, Issue 4 , pp 913-920
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- Springer Berlin Heidelberg
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- 7 Tesla
- Ultra-high field
- High resolution
- Breast cancer
- Industry Sectors
- Author Affiliations
- 1. Department of Biomedical Imaging and Image-guided Therapy, Division of Molecular and Gender Imaging, Medical University Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria
- 2. Department of Biomedical Imaging and Image-guided Therapy, MR Centre of Excellence, Medical University Vienna, Vienna, Austria
- 3. Department of Radiology, King’s College, London, UK
- 4. Department of Surgery, Medical University Vienna, Vienna, Austria
- 5. Department of Pathology, Medical University Vienna, Vienna, Austria