European Radiology

, Volume 23, Issue 12, pp 3509–3516

Computed diffusion-weighted imaging using 3-T magnetic resonance imaging for prostate cancer diagnosis

Authors

    • Department of RadiologyKobe University Graduate School of Medicine
  • Satoru Takahashi
    • Department of RadiologyKobe University Graduate School of Medicine
  • Kazuhiro Kitajima
    • Department of RadiologyKobe University Graduate School of Medicine
  • Tokunori Kimura
    • Toshiba Medical Systems Corp.
  • Ikuo Aoki
    • Toshiba Medical Systems Corp.
  • Fumi Kawakami
    • Department of PathologyKobe University Graduate School of Medicine
  • Hideaki Miyake
    • Department of UrologyKobe University Graduate School of Medicine
  • Yoshiharu Ohno
    • Department of RadiologyKobe University Graduate School of Medicine
    • Advanced Biomedical Imaging ResearchKobe University Graduate School of Medicine
  • Kazuro Sugimura
    • Department of RadiologyKobe University Graduate School of Medicine
Urogenital

DOI: 10.1007/s00330-013-2958-z

Cite this article as:
Ueno, Y., Takahashi, S., Kitajima, K. et al. Eur Radiol (2013) 23: 3509. doi:10.1007/s00330-013-2958-z

Abstract

Objective

To assess the efficacy of computed diffusion-weighted images (cDWIs) of b = 2000 s/mm2 (cDWI2000) generated from DWIs of b = 0 and 1000 for prostate cancer (PCa) diagnosis in comparison with that of measured original DWIs of b = 1000 (mDWI1000) and b = 2000(mDWI2000) using 3-T MRI.

Methods

Eighty patients who underwent a preoperative MRI examination, including T2WI and DWI (b = 0, 1000, 2000 s/mm2), were enrolled in this study. Four combinations of images, protocol A (T2WI alone), B (T2WI + mDWI1000), C (T2WI + mDWI2000) and D (T2WI + cDWI2000), were assessed for their diagnostic capability. Areas under the receiver operating characteristic curve (Az) and diagnostic performance were evaluated, as well as contrast ratios (CR) between cancerous and non-cancerous lesions for each DWI.

Results

The highest CR was obtained with cDWI2000 (0.29 ± 0.16). Sensitivity, specificity, accuracy, and Az of the protocols were: A: 66.3 %, 59.4 %, 63.0 %, 0.67; B: 82.6 %, 62.0 %, 72.5 %, 0.80; C: 84.1 %, 66.5 %, 75.5 %, 0.86; D: 83.2 %, 70.0 %, 76.6 %, and 0.84, respectively The specificities and accuracies of protocol C and D were significantly higher than those of protocol B (P < 0.05).

Conclusion

cDWI2000 appears to be more effective than mDWI1000, and at least as effective as mDWI2000 for PCa diagnosis.

Key Points

• Computed diffusion-weighted MRI with over b1000s/mm2is useful for prostate cancer detection.

• Computed DWI produces any b-value images with two different b-value images.

• DWI with computed b2000s/mm2is as valuable as DWI with measured b2000 s/mm2.

Keywords

Prostate cancerComputed diffusion-weighted imagingHigh b-valueMRIDiagnosis

Copyright information

© European Society of Radiology 2013