Calcium at the carotid siphon as an indicator of internal carotid artery stenosis
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- Gotovac, N., Išgum, I., Viergever, M.A. et al. Eur Radiol (2013) 23: 1478. doi:10.1007/s00330-012-2766-x
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Carotid siphon calcification is often visible on unenhanced head CT (UCT), but the relation to proximal carotid artery stenosis (CAS) is unclear. We investigated the association of carotid siphon calcification with the presence of CAS.
This IRB-waived retrospective study included 160 consecutive patients suspected of stroke (age 64 ± 14 years, 63 female) who underwent head UCT and CTA of the head and neck. CAS was rated on CTA as not present or present with non-significant (<50 %), moderate (50–69 %) or significant (≥70 %) stenosis. Presence, shape (on UCT) and volume (on CTA) of carotid siphon calcifications were related to CAS.
Carotid siphon calcification was absent in 41 % of patients and bilateral in 94 % of those with calcifications. Presence, shape and volume of calcification resulted in odds ratios for having significant CAS of 10.1, 3.9 and 8.4, with 95 % CIs of 1.3–79.6, 1.1–14.1 and 2.6–26.8, respectively. Corresponding NPVs were 0.98, 0.98 and 0.96, while PPVs were 0.14, 0.07 and 0.29, respectively.
Absence of calcification in the carotid artery siphon on UCT has high negative predictive value for carotid artery stenosis in patients with suspected stroke. However, siphon calcification is not a reliable indicator of significant carotid artery stenosis.
• Many stroke patients do not have calcification in the carotid artery siphon.
• Carotid stenosis ≥50 % is unlikely in stroke patients without siphon calcification.
• Carotid siphon calcium is a poor indicator of significant carotid artery stenosis.
KeywordsAtherosclerosisIntracranial atherosclerosisInternal carotid arteryVascular calcificationCarotid stenosis
Proximal internal carotid artery stenosis
95 % confidence interval
Computed tomography angiography
Unenhanced computed tomography
Positive predictive value
Negative predictive value
Transitory ischaemic attack