, Volume 23, Issue 5, pp 1297-1298
Date: 24 Nov 2012

Letter to the Editor re: Perfusion MRI for the prediction of treatment response after preoperative chemoradiotherapy in locally advanced rectal cancer

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Key Points

Rectal cancer treatment can be monitored by perfusion MRI.

Ktrans values vary between responders and non-responders.

Radiation and chemotherapy may affect Ktrans differently.

Dear Editor,

We congratulate Lim et al. [1] on their study investigating DCE-MRI and rectal cancer. In this well-performed and important study, the authors found that pretreatment Ktrans was able to distinguish between responders and non-responders to neoadjuvant chemoradiation in locally advanced, circumferential margin-threatened T3 tumours. Having performed a similar study, published in the same journal, Gollub et al. [2] did not find that pretreatment Ktrans had predictive value, but rather that post-treatment Ktrans in a select group of patients undergoing neoadjuvant chemotherapy only was able to distinguish pathological complete responders from incomplete responders. As the authors of that article, we would like to make several comments, while at the same time emphasise, along with Lim et al., t

This comment refers to the article available at: http://dx.doi.org/10.1007/s00330-012-2416-3.